Zhu Ming, Yu Bing-Bing, Zhai Ji-Liang, Sun Gang
Department of Medical Imaging, Jinan Military General Hospital, Jinan, China.
Department of Radiology, The Branch of Taian Central Hospital, Taian, China.
J Korean Neurosurg Soc. 2016 Mar;59(2):165-7. doi: 10.3340/jkns.2016.59.2.165. Epub 2016 Feb 29.
Langerhans cell histiocytosis (LCH) is a rare disorder histologically characterized by the proliferation of Langerhans cells. Here we present the case of a 13-year-old girl with LCH wherein CT and MRI results led us to an initially incorrect diagnosis of meningioma. The diagnosis was corrected to LCH based on pathology findings. An intracranial mass was found mainly in the dura mater, with thickening of the surrounding dura. It appeared to be growing downward from the calvaria, pressing on underlying brain tissue, and had infiltrated the inner skull, causing a bone defect. The lesion was calcified with the typical dural tail sign. The dural origin of the lesion was verified upon surgical dissection. There are no previous reports in the literature describing LCH of dural origin presenting in young patients with typical dural tail signs and meningioma-like imaging findings. The current case report underscores the need for thorough histological and immunocytochemical examinations in LCH differential diagnosis.
朗格汉斯细胞组织细胞增多症（LCH）是一种罕见疾病，组织学上以朗格汉斯细胞增殖为特征。在此，我们报告一例13岁患LCH的女孩，其CT和MRI结果最初导致我们误诊为脑膜瘤。基于病理结果，诊断被纠正为LCH。颅内肿块主要位于硬脑膜，周围硬脑膜增厚。它似乎从颅骨向下生长，压迫下方脑组织，并已浸润内颅骨，导致骨缺损。病变有钙化，伴有典型的硬脑膜尾征。手术解剖证实病变起源于硬脑膜。文献中以前没有报道描述年轻患者中起源于硬脑膜的LCH出现典型硬脑膜尾征和类似脑膜瘤的影像学表现。本病例报告强调了在LCH鉴别诊断中进行全面组织学和免疫细胞化学检查的必要性。
