Singh Suyash, Kumar Arushi, Pandey Satyadeo, Kumar Raj, Singh Ipra, Kumari Niraj
Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, India.
MDM Hospital and Medical College, Jodhpur, Rajasthan, India.
J Pediatr Neurosci. 2019 Jan-Mar;14(1):46-51. doi: 10.4103/jpn.JPN_72_18.
The histiocytic disorders are pathological diagnosis and rarely affects spine. The spinal involvement is characterized by lytic lesions and painful symptoms. Isolated intradural extramedullary involvement is rare presentation. A 15-year-old female patient presented with nontraumatic cervical compressive myelopathy and was operated electively with preoperative diagnosis of meningioma. The histopathology was surprisingly Langerhans cell histiocytosis. In lineage of histiocytic development, the Langerhans cells develop into matured dendritic cells and lose its Birbeck granules and CD1a antigenicity. With the understanding of histiocyte lineage system, the disorders concerned with central nervous system are classified into dendritic cell disorders and macrophages-related disorders. In this article, we have discussed on histiocytic disorders of central nervous system and management guidelines in case one comes across such histopathology.
组织细胞疾病属于病理诊断范畴，很少累及脊柱。脊柱受累的特征是溶骨性病变和疼痛症状。孤立的硬脊膜内髓外受累是一种罕见的表现。一名15岁女性患者因非创伤性颈段压迫性脊髓病就诊，术前诊断为脑膜瘤并接受了择期手术。组织病理学结果令人惊讶地显示为朗格汉斯细胞组织细胞增多症。在组织细胞发育谱系中，朗格汉斯细胞发育为成熟的树突状细胞，并失去其伯贝克颗粒和CD1a抗原性。随着对组织细胞谱系系统的认识，与中枢神经系统相关的疾病被分为树突状细胞疾病和巨噬细胞相关疾病。在本文中，我们讨论了中枢神经系统的组织细胞疾病以及遇到此类组织病理学情况时的管理指南。
