肺炎克雷伯菌五株临床分离株的基因组序列
Genome Sequences of Five Clinical Isolates of Klebsiella pneumoniae.
作者信息
Lopez L Letti, Rusconi Brigida, Gildersleeve Heidi, Qi Chao, McLaughlin Milena, Scheetz Marc H, Seshu J, Eppinger Mark
机构信息
South Texas Center for Emerging Infectious Diseases, Center for Excellence in Infection Genomics and Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA.
Northwestern University Feinberg School of Medicine, Evanston, Illinois, USA.
出版信息
Genome Announc. 2016 Mar 10;4(2):e00040-16. doi: 10.1128/genomeA.00040-16.
Abstract
Klebsiella pneumoniae is a nosocomial pathogen of emerging importance and displays resistance to broad-spectrum antibiotics, such as carbapenems. Here, we report the genome sequences of five clinical K. pneumoniae isolates, four of which are carbapenem resistant. Carbapenem resistance is conferred by hydrolyzing class A β-lactamases found adjacent to transposases.
摘要
肺炎克雷伯菌是一种新出现的重要医院病原体，对碳青霉烯类等广谱抗生素具有耐药性。在此，我们报告了5株临床肺炎克雷伯菌分离株的基因组序列，其中4株对碳青霉烯类耐药。碳青霉烯类耐药性是由位于转座酶附近的A类β-内酰胺酶水解所致。
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