Gussenhoven E J, Essed C E, Frietman P, van Egmond F, Lancée C T, van Kappellen W H, Roelandt J, Serruys P W, Gerritsen G P, van Urk H
Academic Hospital Rotterdam-Dijkzigt, Erasmus University Rotterdam, The Netherlands.
Eur J Vasc Surg. 1989 Dec;3(6):571-6. doi: 10.1016/s0950-821x(89)80134-3.
The feasibility of assessing arterial wall characteristics with an intravascular 40 MHz ultrasonic imaging device was determined in vitro. Ten autopsy specimens of human arteries, with and without atherosclerosis, were studied. A close relationship was observed between the histologic section and the corresponding ultrasonic cross-section with regard to the location, maximum plaque thickness and extent of the atherosclerotic lesion along the circumference of the vessel wall. Based on echogenicity of the atherosclerotic lesion, ultrasound could distinguish four basic types of atherosclerotic plaque components: 1. hypoechoic: a reflection of lipid deposits; 2. soft echoes: reflective of fibromuscular tissue; 3. bright echoes: representative of fibrous tissue; 4. bright echoes with shadowing behind the lesion: representative of calcium deposits. It is anticipated that development of such a catheter-tip imaging system combined with recanalisation methods will be of immense benefit for the precise localisation and identification of vessel wall pathology, precise positioning of a recanalisation instrument (laser device, atherectomy catheter) and subsequent use of this recanalisation procedure and for assessing the effect of recanalisation.
体外研究了使用血管内40兆赫超声成像设备评估动脉壁特征的可行性。研究了10个有或无动脉粥样硬化的人体动脉尸检标本。在组织学切片与相应超声横截面之间，在动脉粥样硬化病变沿血管壁圆周的位置、最大斑块厚度和范围方面观察到密切关系。基于动脉粥样硬化病变的回声性，超声可区分动脉粥样硬化斑块成分的四种基本类型：1. 低回声：脂质沉积的反映；2. 软回声：纤维肌肉组织的反映；3. 强回声：纤维组织的代表；4. 病变后方伴有声影的强回声：钙沉积的代表。预计这种导管尖端成像系统与再通方法相结合的发展，将对血管壁病变的精确定位和识别、再通器械（激光设备、旋切导管）的精确定位以及随后使用这种再通程序和评估再通效果有极大益处。
