Zhang Xinbo, Francis Brian A, Dastiridou Anna, Chopra Vikas, Tan Ou, Varma Rohit, Greenfield David S, Schuman Joel S, Huang David
Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA.
Doheny Eye Institute, University of California-Los Angeles, Los Angeles, CA, USA.
Transl Vis Sci Technol. 2016 Mar 4;5(2):1. doi: 10.1167/tvst.5.2.1. eCollection 2016 Mar.
We studied the effects of age and intraocular pressure (IOP) on retinal nerve fiber layer (NFL) and macular ganglion cell complex (GCC) thickness in normal eyes.
Data from subjects from the multicenter Advanced Imaging for Glaucoma Study (AIGS) were analyzed. The data included yearly visits from the normal subjects in the AIGS study. Fourier-domain optical coherence tomography (FD-OCT) was used to measure retinal NFL and macular GCC on each visit. Mixed effect models were used to evaluate the longitudinal effect of age and IOP on the NFL and GCC thickness. The measurements at baseline were used to examine the cross-sectional effects.
The analysis included 192 eyes (92 participants) from AIGS between 2009 and 2013. The longitudinal analyses showed overall GCC thickness decreased 0.25 ± 0.05 μm per year ( < 0.001) while the overall NFL thickness decreased 0.14 ± 0.07 μm per year ( = 0.04). The cross-sectional analyses showed the GCC thickness was 0.17 ± 0.05 μm thinner per year of baseline age ( < 0.001), while the NFL was 0.21 ± 0.06 μm thinner ( < 0.001). There was no significant IOP effect on either GCC or NFL from either the longitudinal or cross-sectional analysis.
Longitudinal and cross-sectional analyses provided consistent rates of approximately 0.2% per year of age-related thinning in NFL and GCC thicknesses. This is relevant in establishing criteria to detect glaucoma-related thinning (disease progression) in excess of normal aging. IOP does not seem to be a significant confounder for progression analysis.
This study demonstrated the relevance of advanced imaging technology in diagnosing and monitoring glaucoma disease.
我们研究了年龄和眼压（IOP）对正常眼视网膜神经纤维层（NFL）和黄斑神经节细胞复合体（GCC）厚度的影响。
分析了多中心青光眼高级成像研究（AIGS）受试者的数据。数据包括AIGS研究中正常受试者的年度随访数据。每次随访时使用傅里叶域光学相干断层扫描（FD-OCT）测量视网膜NFL和黄斑GCC。使用混合效应模型评估年龄和IOP对NFL和GCC厚度的纵向影响。基线测量用于检查横断面效应。
分析纳入了2009年至2013年间AIGS的192只眼（92名参与者）。纵向分析显示，总体GCC厚度每年下降0.25±0.05μm（P<0.001），而总体NFL厚度每年下降0.14±0.07μm（P=0.04）。横断面分析显示，GCC厚度在基线年龄每增加一岁就变薄0.17±0.05μm（P<0.001），而NFL变薄0.21±0.06μm（P<0.001）。纵向或横断面分析中，IOP对GCC或NFL均无显著影响。
纵向和横断面分析显示，NFL和GCC厚度与年龄相关的变薄率约为每年0.2%，这对于建立检测超过正常衰老的青光眼相关变薄（疾病进展）的标准具有重要意义。IOP似乎不是进展分析的显著混杂因素。
本研究证明了先进成像技术在青光眼疾病诊断和监测中的相关性。
