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缺氧状态下的树突状细胞：氧气短缺如何影响先天免疫和适应性免疫的联系。

Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity.

机构信息

Institut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.

出版信息

J Immunol Res. 2016;2016:5134329. doi: 10.1155/2016/5134329. Epub 2016 Feb 4.

DOI:10.1155/2016/5134329
PMID:26966693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4757696/
Abstract

Dendritic cells (DCs) are considered as one of the main regulators of immune responses. They collect antigens, process them, and present typical antigenic structures to lymphocytes, thereby inducing an adaptive immune response. All these processes take place under conditions of oxygen shortage (hypoxia) which is often not considered in experimental settings. This review highlights how deeply hypoxia modulates human as well as mouse immature and mature dendritic cell functions. It tries to link in vitro results to actual in vivo studies and outlines how hypoxia-mediated shaping of dendritic cells affects the activation of (innate) immunity.

摘要

树突状细胞 (DCs) 被认为是免疫反应的主要调节者之一。它们收集抗原，对其进行处理，并将典型的抗原结构呈现给淋巴细胞，从而诱导适应性免疫反应。所有这些过程都是在缺氧 (hypoxia) 的条件下进行的，而在实验环境中通常不考虑缺氧条件。这篇综述强调了缺氧如何深刻地调节人类以及小鼠未成熟和成熟树突状细胞的功能。它试图将体外结果与实际的体内研究联系起来，并概述了缺氧介导的树突状细胞的形成如何影响 (先天) 免疫的激活。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf52/4757696/43067864d245/JIR2016-5134329.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf52/4757696/43067864d245/JIR2016-5134329.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf52/4757696/43067864d245/JIR2016-5134329.001.jpg

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