Blankenship G W
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33101.
Graefes Arch Clin Exp Ophthalmol. 1989;227(6):565-8. doi: 10.1007/BF02169453.
To evaluate the efficacy and toxicity of 5-fluorouracil (5-FU) after pars plana vitrectomy, 51 eyes were followed in a prospective and randomized clinical trial in which, upon completion of surgery, 26 eyes received 10 mg intravitreal 5-FU and 25 control eyes did not receive 5-FU. The only possible sign of 5-FU toxicity was prolonged corneal epithelial edema. Visual acuities of 20/200 or better were obtained in 67% of the 5-FU group and 56% of the control group. Successful macular reattachment was obtained in 60% of the 5-FU group and 77% of the control group. None of the eyes in either group developed substantial intraocular proliferation or membranes. The findings indicate that a single 10-mg intravitreal injection of 5-FU is well tolerated without permanent toxic damage.
为评估玻璃体切除术联合5-氟尿嘧啶（5-FU）的疗效和毒性，我们进行了一项前瞻性随机临床试验，对51只眼进行了随访。手术完成后，26只眼接受了10mg玻璃体内注射5-FU，25只对照眼未接受5-FU。5-FU毒性的唯一可能迹象是角膜上皮水肿持续时间延长。5-FU组67%的患者和对照组56%的患者视力达到20/200或更好。5-FU组60%的患者和对照组77%的患者黄斑成功复位。两组均无眼内出现大量增殖或形成膜。研究结果表明，单次玻璃体内注射10mg 5-FU耐受性良好，无永久性毒性损伤。
