Fereshteh Zeinab, Nooeaid Patcharakamon, Fathi Mohammadhossein, Bagri Akbar, Boccaccini Aldo R
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany; Institute of Science, High Technology and Environmental Sciences, Graduate University of Advanced Technology, 76315117 Kerman, Iran.
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany.
Data Brief. 2015 Jul 23;4:524-8. doi: 10.1016/j.dib.2015.07.013. eCollection 2015 Sep.
This article presents data related to the research article entitled "The effect of coating type on mechanical properties and controlled drug release of PCL/zein coated 45S5 bioactive glass scaffolds for bone tissue engineering" [1]. We provide data on mechanical properties, in vitro bioactivity and drug release of bioactive glass (BG) scaffolds coated by poly (ε-caprolactone) (PCL) and zein used as a controlled release device for tetracycline hydrochloride (TCH). By coating the BG scaffolds with PCL or PCL/zein blend the mechanical properties of the scaffolds were substantially improved, i.e., the compressive strength increased from 0.004±0.001 MPa (uncoated BG scaffolds) to 0.15±0.02 MPa (PCL/zein coated BG scaffolds). A dense bone-like apatite layer formed on the surface of PCL/zein coated scaffolds immersed for 14 days in simulated body fluid (SBF). The data describe control of drug release and in vitro degradation behavior of coating by engineering the concentration of zein. Thus, the developed scaffolds exhibit attractive properties for application in bone tissue engineering research.
本文展示了与题为《涂层类型对用于骨组织工程的聚己内酯/玉米醇溶蛋白涂层45S5生物活性玻璃支架的力学性能和药物控释的影响》的研究论文相关的数据[1]。我们提供了关于用聚（ε-己内酯）（PCL）和玉米醇溶蛋白涂层的生物活性玻璃（BG）支架的力学性能、体外生物活性和药物释放的数据，该支架用作盐酸四环素（TCH）的控释装置。通过用PCL或PCL/玉米醇溶蛋白共混物涂覆BG支架，支架的力学性能得到了显著改善，即抗压强度从0.004±0.001MPa（未涂层的BG支架）增加到0.15±0.02MPa（PCL/玉米醇溶蛋白涂层的BG支架）。在模拟体液（SBF）中浸泡14天的PCL/玉米醇溶蛋白涂层支架表面形成了致密的骨样磷灰石层。这些数据描述了通过设计玉米醇溶蛋白的浓度来控制药物释放和涂层的体外降解行为。因此，所开发的支架在骨组织工程研究中具有吸引人的应用特性。
