Pisera Malgorzata, Kaminski Michal F, Kraszewska Ewa, Rupinski Maciej, Regula Jaroslaw
aDepartment of Gastroenterological Oncology, the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology bDepartment of Gastroenterology and Hepatology, Medical Center for Postgraduate Education, Warsaw, Poland.
Eur J Gastroenterol Hepatol. 2016 May;28(5):538-42. doi: 10.1097/MEG.0000000000000578.
The response rate to initial invitation to population-based primary screening colonoscopy within the NordICC trial (NCT 00883792) in Poland is around 50%. The aim of this study was to compare the effect of a reinvitation letter and invitation to an educational intervention on participation in screening colonoscopy in nonresponders to initial invitation.
Within the NordICC trial framework, individuals living in the region of Warsaw, who were drawn from Population Registries and assigned randomly to the screening group, received an invitation letter and a reminder with a prespecified screening colonoscopy appointment date. One thousand individuals, aged 55 to 64 years, who did not respond to both the invitation and the reminding letter were assigned randomly in a 1:1 ratio to the reinvitation group (REI) and the educational meeting group (MEET). The REI group was sent a reinvitation letter and reminder 6 and 3 weeks before the new colonoscopy appointment date, respectively. The MEET group was sent an invitation 6 weeks before an educational meeting date. Outcome measures were participation in screening colonoscopy within 6 months and response rate within 3 months from the date of reinvitation or invitation to an educational meeting.
The response rate and the participation rate in colonoscopy were statistically significantly higher in the REI group compared with the MEET group (16.5 vs. 4.3%; P<0.001 and 5.2 vs. 2.1%; P=0.008, respectively).
A simple reinvitation letter results in a higher response rate and participation rate to screening colonoscopy than invitation to tailored educational meeting in nonresponders to previous invitations. (NCT01183156).
在波兰进行的北欧国际癌症筛查协作组（NordICC）试验（NCT 00883792）中，基于人群的初次结肠镜筛查邀请的应答率约为50%。本研究旨在比较再次邀请信和教育干预邀请对初次邀请无应答者参与结肠镜筛查的影响。
在NordICC试验框架内，从人口登记处抽取居住在华沙地区且随机分配到筛查组的个体，收到一封邀请信及带有预先指定结肠镜筛查预约日期的提醒信。1000名年龄在55至64岁之间、对邀请信和提醒信均无应答的个体，以1:1的比例随机分配至再次邀请组（REI）和教育会议组（MEET）。REI组在新的结肠镜检查预约日期前6周和3周分别收到再次邀请信和提醒信。MEET组在教育会议日期前6周收到邀请。观察指标为再次邀请或教育会议邀请日期起6个月内参与结肠镜筛查的情况以及3个月内的应答率。
与MEET组相比，REI组的结肠镜检查应答率和参与率在统计学上显著更高（分别为16.5%对4.3%；P<0.001和5.2%对2.1%；P=0.008）。
对于之前邀请无应答者，简单的再次邀请信比量身定制的教育会议邀请能带来更高的结肠镜筛查应答率和参与率。（NCT01183156）
