Slimano F, Roessle C, Blanc C, De Maleissye M-F, Bauler S
Département de pharmacie clinique, Gustave-Roussy cancer campus, 114, rue Édouard-Vaillant, 94805 Villejuif, France; Laboratoire de pharmacologie et pharmacocinétique, UFR de pharmacie, université de Reims-Champagne-Ardenne, 51, rue Cognacq-Jay, 51100 Reims, France; Unité MEDyC, UMR CNRS/URCA, université de Reims-Champagne-Ardenne, 51, rue Cognacq-Jay, 51100 Reims, France.
Département de pharmacie clinique, Gustave-Roussy cancer campus, 114, rue Édouard-Vaillant, 94805 Villejuif, France.
Ann Pharm Fr. 2016 Sep;74(5):335-49. doi: 10.1016/j.pharma.2016.01.002. Epub 2016 Mar 8.
Melanoma is a skin cancer that represents an actual public health problem. Its incidence is increasing every year. Environmental risk factors have been clearly identified. Early diagnosis of a suspicious skin lesion should be possible by any health professionals because the prognosis is correlated with the evolution of the disease and the presence of metastases. The advent of new therapies in metastatic forms with the development of immunotherapies and kinases inhibitors has significantly changed the management of this disease. New therapies are available in retail pharmacies and involve health professionals out of the hospital. This article is intended for community and hospital pharmacists and summarizes recommendations for primary and secondary prevention. It updates on new targeted therapies. It wants to give advices to the community pharmacists about the effective use of those treatments for melanoma.
黑色素瘤是一种皮肤癌，是一个切实存在的公共卫生问题。其发病率逐年上升。环境风险因素已被明确识别。任何卫生专业人员都应能够对可疑皮肤病变进行早期诊断，因为预后与疾病进展及转移灶的存在相关。随着免疫疗法和激酶抑制剂的发展，转移性黑色素瘤新疗法的出现显著改变了该疾病的治疗方式。新疗法在零售药店有售，且涉及医院以外的卫生专业人员。本文面向社区和医院药剂师，总结了一级和二级预防的建议。介绍了新的靶向治疗方法。旨在就黑色素瘤治疗药物的有效使用向社区药剂师提供建议。
