Celik Yasemin, Yardan Turker, Baydin Ahmet, Demircan Sabri
Department of Emergency Medicine, Bagcilar Education and Research Hospital, Istanbul.
Department of Emergency Medicine, Ondokuz Mayis University Medical Faculty, Samsun, Turkey.
J Pak Med Assoc. 2016 Mar;66(3):306-11.
To investigate the role of N-terminal pro-brain natriuretic peptide and apelin in the assessment of right ventricular dysfunction in acute pulmonary embolism.
The prospective case-control study was conducted at Ondokuz Mayis University, Samsun, Turkey, from January 2008 to June 2009, and comprised adult patients with acute pulmonary embolism. A smaller group of healthy adults served as the control. Blood N-terminal pro-brain natriuretic peptide and apelin levels were measured on admission to the Emergency Department. SPSS 15 was used for data analysis.
There were 56 cases and 20 controls in the study. Blood N-terminal pro-brain natriuretic peptide levels were higher in cases than the controls (p<0.05). Apelin levels were not different between the groups (p>0.05). Patients with right ventricular dysfunction had significantly higher peptide levels than those without the dysfunction (p<0.05). The cut-off value of peptide for the prediction of right ventricular dysfunction was 1000 pg/ml, with a sensitivity of 92.1% and specificity of 77.8%.
There was no significant change in plasma apelin levels in acute pulmonary embolism. The blood N-terminal pro-brain natriuretic peptide maybe a useful parameter in the assessment of right ventricular dysfunction in acute pulmonary embolism.
探讨N末端脑钠肽前体和Apelin在急性肺栓塞右心室功能障碍评估中的作用。
2008年1月至2009年6月在土耳其萨姆松的于库祖梅利斯大学进行了一项前瞻性病例对照研究，纳入成年急性肺栓塞患者。一小群健康成年人作为对照。在急诊科入院时测量血液N末端脑钠肽前体和Apelin水平。使用SPSS 15进行数据分析。
研究中有56例病例和20例对照。病例组血液N末端脑钠肽前体水平高于对照组（p<0.05）。两组间Apelin水平无差异（p>0.05）。右心室功能障碍患者的肽水平显著高于无功能障碍患者（p<0.05）。预测右心室功能障碍的肽截断值为1000 pg/ml，敏感性为92.1%，特异性为77.8%。
急性肺栓塞患者血浆Apelin水平无显著变化。血液N末端脑钠肽前体可能是评估急性肺栓塞右心室功能障碍的有用参数。
