血清腺苷酸脱氨酶对急性肺栓塞初步排除的诊断准确性：一项前瞻性研究。

Diagnostic accuracy of adropin as a preliminary test to exclude acute pulmonary embolism: a prospective study.

机构信息

Emergency Medicine Department, Namık Kemal University Medicine Faculty, Tekirdağ, Turkey.

Medical Biochemistry Department, Namık Kemal University Medicine Faculty, Tekirdağ, Turkey.

出版信息

BMC Pulm Med. 2022 Sep 18;22(1):351. doi: 10.1186/s12890-022-02156-y.

DOI:10.1186/s12890-022-02156-y

PMID:36115957

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9482749/

Abstract

BACKGROUND

This study aims to investigate the diagnostic accuracy of adropin as a biomarker to exclude the diagnosis of acute pulmonary embolism (PE).

METHODS

Patients admitted to the emergency department of a tertiary health centre between August 2019 and August 2020 and diagnosed with PE were included in this prospective cohort study. The amount of serum adropin was determined in patients with (PE) and compared with that of healthy volunteers. Receiver operating characteristic analysis was performed with the obtained data, and the area under the curve (AUC) with a 95% confidence interval was determined. The parameters of diagnostic accuracy for PE were determined.

RESULTS

A total of 57 participants were included in the study (28 controls and 29 PE patients). The mean adropin level in the PE group was 187.33 ± 62.40 pg/ml, which was significantly lower than that in the control group (524.06 ± 421.68 pg/ml) (p < 0.001). When the optimal adropin cut-off value was 213.78 pg/ml, the likelihood ratio of the adropin test was 3.4, and the sensitivity of the adropin test at this value was 82% with specificity of 75% (95% CI; AUC: 0.821).

CONCLUSION

Our results suggest that adropin may be considered for further study as a candidate marker for the exclusion of the diagnosis of PE. However, more research is required to verify and support the generalizability of our study results.

摘要

背景

本研究旨在探讨 adropin 作为一种生物标志物用于排除急性肺栓塞（PE）诊断的准确性。

方法

本前瞻性队列研究纳入了 2019 年 8 月至 2020 年 8 月期间在三级保健中心急诊科就诊并诊断为 PE 的患者。测定患者血清 adropin 含量，并与健康志愿者进行比较。对获得的数据进行受试者工作特征（ROC）分析，确定曲线下面积（AUC）及其 95%置信区间。确定用于诊断 PE 的诊断准确性参数。

结果

共纳入 57 名患者（对照组 28 例，PE 组 29 例）。PE 组 adropin 水平的平均值为 187.33±62.40pg/ml，明显低于对照组（524.06±421.68pg/ml）（p<0.001）。当最佳 adropin 截断值为 213.78pg/ml 时，adropin 检验的似然比为 3.4，此时 adropin 检验的敏感性为 82%，特异性为 75%（95%CI；AUC：0.821）。