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[阻塞性睡眠呼吸暂停低通气综合征诊断标准]

[Diagnostic criteria for obstructive sleep apnea syndrome].

作者信息

Beydon N, Aubertin G

机构信息

Unité fonctionnelle de physiologie, explorations fonctionnelles respiratoires et du sommeil, hôpital Armand-Trousseau, AP-HP, 26, avenue du Docteur-Arnold-Netter, 75012 Paris, France; Inserm U 938, centre de recherche Saint-Antoine, hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.

Inserm U 938, centre de recherche Saint-Antoine, hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France; Service de pneumologie pédiatrique, centre de références des maladies respiratoires rares de l'enfant, hôpital Armand-Trousseau, AP-HP, 26, avenue du Docteur-Arnold-Netter, 75012 Paris, France.

出版信息

Arch Pediatr. 2016 Apr;23(4):432-6. doi: 10.1016/j.arcped.2016.01.002. Epub 2016 Mar 8.

DOI:10.1016/j.arcped.2016.01.002
PMID:26968302
Abstract

The prevalence of obstructive sleep apnea syndrome (OSAS) is 1-4 % in school-aged children. Adenotonsillar hypertrophy is the most common etiology of OSAS in children. Other causes are obesity; facial or skeletal malformations; and neuromuscular, respiratory, or metabolic diseases. OSAS has been associated with sleep quality disturbance (frequent arousals) and nocturnal gas exchange abnormalities (hypoxemia and sometimes hypercapnia), which can both result in negative health outcomes. The analysis of clinical symptoms and physical examination cannot always distinguish between children with primary snoring and children with OSAS. However, the association of at least one sign of nocturnal upper airway obstruction with other diurnal or nocturnal symptoms can be sufficient to establish OSAS diagnosis in a child more than 3 years of age with clear enlarged tonsils but who is otherwise healthy. In all other cases, polysomnography (the gold standard for the diagnosis of sleep-disordered breathing) must be performed either to declare the diagnosis when clinical assessment is not conclusive or when risk factors are present, or to follow up children with an associated health condition or initial severe OSAS. The equipment used to record sleep and the interpretation criteria are all pediatric-specific. Other methods, such as respiratory polygraphy, are simpler to implement, but further studies are warranted to validate the interpretation criteria of these methods in children. However, in centers with experienced personnel, polygraphy can be used in place of polysomnography. In all cases, the analysis of sleep traces must be manual and performed by personnel under the supervision of medical staff trained to interpret pediatric sleep studies.

摘要

阻塞性睡眠呼吸暂停综合征(OSAS)在学龄儿童中的患病率为1%-4%。腺样体扁桃体肥大是儿童OSAS最常见的病因。其他病因包括肥胖、面部或骨骼畸形以及神经肌肉、呼吸或代谢疾病。OSAS与睡眠质量紊乱(频繁觉醒)和夜间气体交换异常(低氧血症,有时伴有高碳酸血症)有关,这两者都可能导致不良健康后果。临床症状分析和体格检查并不总能区分原发性打鼾儿童和OSAS儿童。然而,对于3岁以上扁桃体明显肿大但其他方面健康的儿童,夜间上气道阻塞的至少一个体征与其他日间或夜间症状相关,这足以确诊OSAS。在所有其他情况下,必须进行多导睡眠图检查(诊断睡眠呼吸障碍的金标准),以便在临床评估不确定或存在危险因素时明确诊断,或者对患有相关健康状况或初始严重OSAS的儿童进行随访。用于记录睡眠的设备和解读标准均针对儿童。其他方法,如呼吸多导记录法,实施起来更简单,但需要进一步研究以验证这些方法在儿童中的解读标准。然而,在有经验丰富人员的中心,多导记录法可用于替代多导睡眠图检查。在所有情况下,睡眠记录的分析必须人工进行,且由在经过培训以解读儿科睡眠研究的医务人员监督下的人员完成。

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