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基于流行病学和基因分析的银屑病与其他疾病之间的联系。

The link between psoriasis and other diseases based on epidemiological and genetic analyses.

作者信息

Adamski Zygmunt, Kanabaj Krzysztof, Kuźniak Aleksandra

机构信息

Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

出版信息

Postepy Dermatol Alergol. 2023 Aug;40(4):496-503. doi: 10.5114/ada.2023.130518. Epub 2023 Sep 1.

DOI:10.5114/ada.2023.130518
PMID:37692276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10485754/
Abstract

Psoriasis is a chronic disease, which is associated with numerous genetic and environmental factors. The high prevalence of psoriasis worldwide (2-3% of the general population) and its various comorbidities lead to research on its pathogenesis. The aim of this article is to describe the current state of knowledge on the potential links between psoriasis and other diseases, such as inflammatory bowel diseases, uveitis, arthritis, hypertension, metabolic syndrome, diabetes mellitus, atherosclerosis, fatty liver disease, dyslipidaemia, sleep apnoea, celiac disease, lymphoma, erectile dysfunction, Parkinson's disease, osteoporosis, chronic obstructive pulmonary disease, psychiatric disorders and substance use. Further research in this area may lead to better treatment options in the future.

摘要

银屑病是一种慢性疾病,与众多遗传和环境因素相关。银屑病在全球的高患病率(占普通人群的2%-3%)及其各种合并症引发了对其发病机制的研究。本文旨在描述目前关于银屑病与其他疾病(如炎症性肠病、葡萄膜炎、关节炎、高血压、代谢综合征、糖尿病、动脉粥样硬化、脂肪肝疾病、血脂异常、睡眠呼吸暂停、乳糜泻、淋巴瘤、勃起功能障碍、帕金森病、骨质疏松症、慢性阻塞性肺疾病、精神障碍和物质使用)之间潜在联系的知识现状。该领域的进一步研究可能会在未来带来更好的治疗选择。

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本文引用的文献

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Non-alcoholic fatty liver disease is not a causal risk factor for psoriasis: A Mendelian randomization study of 108,835 individuals.非酒精性脂肪性肝病不是银屑病的因果风险因素:对 108835 人的孟德尔随机研究。
Front Immunol. 2022 Oct 24;13:1022460. doi: 10.3389/fimmu.2022.1022460. eCollection 2022.
2
Sexual Dysfunction in Women and Men with Psoriasis: A Cross-Sectional Questionnaire-Based Study.银屑病患者的男女性性功能障碍:一项基于横断面问卷调查的研究。
Medicina (Kaunas). 2022 Oct 13;58(10):1443. doi: 10.3390/medicina58101443.
3
Association Between Inflammatory Bowel Disease and Both Psoriasis and Psoriatic Arthritis: A Bidirectional 2-Sample Mendelian Randomization Study.炎症性肠病与银屑病及银屑病关节炎之间的关联:一项双向双样本孟德尔随机化研究。
JAMA Dermatol. 2022 Sep 14;158(11):1262-8. doi: 10.1001/jamadermatol.2022.3682.
4
Psoriasis and Cardiometabolic Diseases: Shared Genetic and Molecular Pathways.银屑病与心血管代谢疾病:共同的遗传和分子途径。
Int J Mol Sci. 2022 Aug 13;23(16):9063. doi: 10.3390/ijms23169063.
5
More than a random association between chronic obstructive pulmonary disease and psoriatic arthritis: shared pathogenic features and implications for treatment.慢性阻塞性肺疾病与银屑病关节炎之间不仅仅是随机关联:共同的发病特征及治疗意义。
Expert Rev Clin Immunol. 2022 Sep;18(9):983-990. doi: 10.1080/1744666X.2022.2106969. Epub 2022 Aug 1.
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Psoriasis and progression of Parkinson's disease: a Mendelian randomization study.银屑病与帕金森病进展:一项孟德尔随机研究。
J Eur Acad Dermatol Venereol. 2022 Dec;36(12):2401-2405. doi: 10.1111/jdv.18459. Epub 2022 Aug 9.
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The Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis.银屑病患者超重和肥胖的全基因组关联研究分析。
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