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基于流行病学和基因分析的银屑病与其他疾病之间的联系。

The link between psoriasis and other diseases based on epidemiological and genetic analyses.

作者信息

Adamski Zygmunt, Kanabaj Krzysztof, Kuźniak Aleksandra

机构信息

Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

出版信息

Postepy Dermatol Alergol. 2023 Aug;40(4):496-503. doi: 10.5114/ada.2023.130518. Epub 2023 Sep 1.

Abstract

Psoriasis is a chronic disease, which is associated with numerous genetic and environmental factors. The high prevalence of psoriasis worldwide (2-3% of the general population) and its various comorbidities lead to research on its pathogenesis. The aim of this article is to describe the current state of knowledge on the potential links between psoriasis and other diseases, such as inflammatory bowel diseases, uveitis, arthritis, hypertension, metabolic syndrome, diabetes mellitus, atherosclerosis, fatty liver disease, dyslipidaemia, sleep apnoea, celiac disease, lymphoma, erectile dysfunction, Parkinson's disease, osteoporosis, chronic obstructive pulmonary disease, psychiatric disorders and substance use. Further research in this area may lead to better treatment options in the future.

摘要

银屑病是一种慢性疾病,与众多遗传和环境因素相关。银屑病在全球的高患病率(占普通人群的2%-3%)及其各种合并症引发了对其发病机制的研究。本文旨在描述目前关于银屑病与其他疾病(如炎症性肠病、葡萄膜炎、关节炎、高血压、代谢综合征、糖尿病、动脉粥样硬化、脂肪肝疾病、血脂异常、睡眠呼吸暂停、乳糜泻、淋巴瘤、勃起功能障碍、帕金森病、骨质疏松症、慢性阻塞性肺疾病、精神障碍和物质使用)之间潜在联系的知识现状。该领域的进一步研究可能会在未来带来更好的治疗选择。

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本文引用的文献

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Psoriasis and progression of Parkinson's disease: a Mendelian randomization study.银屑病与帕金森病进展:一项孟德尔随机研究。
J Eur Acad Dermatol Venereol. 2022 Dec;36(12):2401-2405. doi: 10.1111/jdv.18459. Epub 2022 Aug 9.
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Sleep Disorders and Psoriasis: An Update.睡眠障碍与银屑病:最新研究进展。
Acta Derm Venereol. 2022 Apr 27;102:adv00699. doi: 10.2340/actadv.v102.1991.
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Associations between psoriasis and mental illness: an update for clinicians.银屑病与精神疾病之间的关联:临床医生最新资讯
Gen Hosp Psychiatry. 2022 Mar-Apr;75:30-37. doi: 10.1016/j.genhosppsych.2022.01.006. Epub 2022 Jan 25.

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