姬松茸生物质作为食品补充剂的安全性评估。
A safety assessment of Coriolus versicolor biomass as a food supplement.
机构信息
Global Health and Tropical Medicine, Institute of Hygiene and Tropical Medicine, New University of Lisbon, Lisbon, Portugal;
Ministry of Education, Maputo, Mozambique.
出版信息
Food Nutr Res. 2016 Mar 10;60:29953. doi: 10.3402/fnr.v60.29953. eCollection 2016.
BACKGROUND
Coriolus versicolor (CV) is a common mushroom with antitumor, anti-inflammatory, antioxidant, antiviral, antibacterial, and immunomodulatory properties. The existence of these properties has been extensively proven mainly using CV extract; research on the biomass form is scarce.
OBJECTIVE
The aim of this study was to investigate the safety of the CV biomass form, as it is commonly used as a food supplement.
DESIGN
CV biomass powder was dissolved in distilled water and administered daily (2.5, 5.0, and 7.5 g/kg live weight) in single doses by gavage to both female and male Charles River albino rats.
RESULTS
No adverse or lethal effects were observed as a consequence of the daily administration of CV biomass. In addition, compared with the control group, no abnormal findings were observed at necropsy and histopathological examination.
CONCLUSIONS
A safe profile of CV biomass for human consumption can be inferred from the absence of any remarkable adverse effects in rats.
背景
云芝（CV）是一种常见的蘑菇，具有抗肿瘤、抗炎、抗氧化、抗病毒、抗菌和免疫调节特性。这些特性的存在主要通过 CV 提取物得到了广泛证明；对生物量形式的研究则相对较少。
目的
本研究旨在调查 CV 生物量形式的安全性，因为它通常被用作食品补充剂。
设计
将 CV 生物量粉末溶解在蒸馏水中，并通过灌胃每天（2.5、5.0 和 7.5 g/kg 活体重）给予雄性和雌性 Charles River 白化大鼠单次剂量。
结果
由于每日给予 CV 生物量，没有观察到不良反应或致死作用。此外，与对照组相比，尸检和组织病理学检查均未观察到异常发现。
结论
从大鼠中没有观察到任何显著的不良反应，可以推断 CV 生物量可安全供人类食用。
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