全身给药的N-甲基-D-天冬氨酸会干扰大鼠被动回避反应的习得。
Systemically administered N-methyl-D-aspartate interferes with acquisition of a passive avoidance response in rats.
作者信息
Jones K W, Schaeffer C L, DeNoble V J
机构信息
E. I. duPont de Nemours & Co., Inc., Medical Products Department, Wilmington, DE 19880-0400.
出版信息
Pharmacol Biochem Behav. 1989 Sep;34(1):181-5. doi: 10.1016/0091-3057(89)90370-5.
The effect of several doses of systemically administered N-methyl-D-aspartate (NMDA) was studied on step-through passive avoidance (PA) retention in rats. Retention of single trial PA was significantly reduced by preacquisition (30 minutes) doses of NMDA (3, 10, 30, and 50 mg/kg SC). Preacquisition amnesia was found when NMDA (30 mg/kg SC) was administered between two and 60 minutes. At shorter and longer pretreatment times (0.5 and 180 minutes) NMDA (30 mg/kg SC) did not disrupt retention testing. Across the same dose range and pretreatment times, NMDA failed to interfere with PA retention when given after acquisition or before retention testing. The results suggest that systemic NMDA administration can interfere with the acquisition of a PA response but does not alter consolidation of information or retrieval.
研究了多次全身给予N-甲基-D-天冬氨酸（NMDA）对大鼠穿梭箱被动回避（PA）记忆保持的影响。在获得训练前（30分钟）给予NMDA（3、10、30和50mg/kg皮下注射），单次试验PA的记忆保持显著降低。当在训练前2至60分钟给予NMDA（30mg/kg皮下注射）时，发现存在获得训练前遗忘现象。在较短和较长的预处理时间（0.5和180分钟）给予NMDA（30mg/kg皮下注射）时，并未干扰记忆保持测试。在相同剂量范围和预处理时间内，在训练后或记忆保持测试前给予NMDA，未能干扰PA记忆保持。结果表明，全身给予NMDA可干扰PA反应的获得，但不会改变信息的巩固或提取。
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