原发性激光辅助治疗后复发性声门癌的挽救性经口激光显微手术：预后因素分析
Salvage transoral laser microsurgery for recurrent glottic carcinoma after primary laser-assisted treatment: Analysis of prognostic factors.
作者信息
Lucioni Marco, Bertolin Andy, Lionello Marco, Giacomelli Luciano, Rizzotto Giuseppe, Marioni Gino
机构信息
Otolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Italy.
Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.
出版信息
Head Neck. 2016 Jul;38(7):1043-9. doi: 10.1002/hed.24414. Epub 2016 Mar 11.
BACKGROUND
Treatment for local glottic cancer recurrences after primary transoral laser microsurgery (TLM) has not been standardized.
METHODS
In 33 consecutive cases of salvage TLM after laser surgery for early glottic carcinoma failed, we retrospectively considered the potential clinicopathological prognostic factors in univariate statistical setting.
RESULTS
Patient age <65 years and pathological involvement of the deep margins were associated with a higher second recurrence rate and shorter disease-free survival.
CONCLUSION
The age of the patient and the pathological status of surgical margins after salvage TLM could be useful for planning a closer endoscopic/radiological follow-up in selected patients at high risk of recurrence. Other appropriately designed studies are needed to see if an open surgical approach should be considered for younger patients (<65 years old) with recurrent glottic carcinoma after primary TLM. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1043-1049, 2016.
背景
原发性经口激光显微手术（TLM）后局部声门癌复发的治疗尚未标准化。
方法
在33例早期声门癌激光手术后挽救性TLM失败的连续病例中，我们在单变量统计分析中回顾性地考虑了潜在的临床病理预后因素。
结果
患者年龄<65岁以及深部切缘的病理累及与较高的二次复发率和较短的无病生存期相关。
结论
挽救性TLM后患者的年龄和手术切缘的病理状态对于计划对复发高危的特定患者进行更密切的内镜/放射学随访可能有用。需要其他设计合理的研究来确定对于原发性TLM后复发性声门癌的年轻患者（<65岁）是否应考虑采用开放手术方法。©2016威利期刊公司。头颈外科38: 1043 - 1049, 2016年。
Zotero 插件