生物运动诱发的 mu 抑制在有活跃阴性症状的早期精神病 (EP) 患者和自闭症谱系障碍 (ASD) 患者中减少。

Biological Motion induced mu suppression is reduced in Early Psychosis (EP) patients with active negative symptoms and Autism Spectrum Disorders (ASD).

机构信息

Department of Psychiatry, University of California at San Diego (UCSD), San Diego, CA, USA; Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.

Department of Psychiatry, University of California at San Diego (UCSD), San Diego, CA, USA.

出版信息

Psychiatry Res. 2016 Apr 30;238:374-377. doi: 10.1016/j.psychres.2016.01.057. Epub 2016 Jan 26.

DOI:10.1016/j.psychres.2016.01.057

PMID:26970656

Abstract

There is evidence of genetic and neural system overlap in Autism Spectrum Disorder (ASD) and Early Psychosis (EP). Five datasets were pooled to compare mu suppression index (MSI), a proxy of mirror neuron activity, in EP, high functioning ASD, and healthy subjects (HS). ASDs and EPs with "active" negative symptoms showed significant differences in mu suppression, in response to Biological Motion/point-light display animation, compared to HS. Preliminary findings suggest that similar neural network deficits in ASD and EP could be driven by the expression of negative symptoms in the latter group of patients. These findings may aid future studies on EP and ASD and facilitate the formulation of new hypotheses regarding their pathophysiology.

摘要

自闭症谱系障碍（ASD）和早期精神病（EP）存在遗传和神经系统重叠的证据。汇集了五个数据集，以比较镜像神经元活动的代理物——运动诱发电位指数（MSI），在 EP、高功能 ASD 和健康对照组（HS）中的差异。与 HS 相比，具有“活跃”阴性症状的 ASDs 和 EPs 在对生物运动/点光显示动画的反应中，表现出明显的运动诱发电位抑制差异。初步研究结果表明，后者组患者的阴性症状表达可能导致 ASD 和 EP 中类似的神经网络缺陷。这些发现可能有助于未来对 EP 和 ASD 的研究，并为它们的病理生理学提出新的假说。