Hourigan Suchitra K, Ta Allison, Wong Wendy S W, Clemency Nicole C, Provenzano Marina G, Baveja Rajiv, Iyer Ramaswamy, Klein Elisabeth, Niederhuber John E
Inova Translational Medicine Institute, Fairfax, Virginia; Inova Children's Hospital, Fairfax, Virginia; Pediatric Specialists of Virginia, Fairfax, Virginia; Johns Hopkins School of Medicine, Baltimore, Maryland.
Inova Children's Hospital, Fairfax, Virginia.
Clin Ther. 2016 Apr;38(4):747-53. doi: 10.1016/j.clinthera.2016.02.014. Epub 2016 Mar 9.
Our case describes the serial microbiome changes in twins discordant for necrotizing enterocolitis (NEC), who shared similar intrauterine and early environmental exposures. The key findings were that the 2 neonates had distinctly different microbiome compositions from the first stool samples collected. Also, in the twin who developed NEC there was a decrease in bacterial diversity and an increase in Proteobacteria a week before developing any clinical symptoms, suggesting an early role of the intestinal microbiome in the development of NEC. Here we briefly review the literature on the role of the intestinal microbiome in NEC and how a greater understanding of the neonatal microbiome and host interactions may help mitigate this devastating disease.
我们的病例描述了患坏死性小肠结肠炎（NEC）的双胞胎之间微生物群的系列变化，这对双胞胎在子宫内和早期环境暴露方面相似。关键发现是，从首次采集的粪便样本来看，这两名新生儿的微生物群组成明显不同。此外，在患NEC的双胞胎中，在出现任何临床症状前一周，细菌多样性降低，变形菌门增加，这表明肠道微生物群在NEC的发生中起早期作用。在此，我们简要回顾关于肠道微生物群在NEC中的作用的文献，以及对新生儿微生物群和宿主相互作用的更深入理解如何有助于减轻这种毁灭性疾病。
