Department of Plastic and Reconstructive Surgery, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Department of Plastic and Reconstructive Surgery, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Colloids Surf B Biointerfaces. 2016 Jun 1;142:315-324. doi: 10.1016/j.colsurfb.2016.02.038. Epub 2016 Feb 18.
Chitosan films were synthesized with hexagonal silver nanoparticles (Ag NP). The unique shape and size of the Ag NP shift the optical absorption into the infrared. Stimulation of the nanoparticles with infrared light was used to generate heat and facilitate intracellular delivery of fluorescently-labeled dextran molecules. Chitosan films prepared with hexagonal or spherical Ag NP were characterized by optical and thermal analyses, and X-ray diffraction. There were found to be slight differences between how the chitosan molecular chains interface with the Ag NP depending upon shape of the nanoparticle. Viability of cells associated with dermal wound healing was evaluated on chitosan films prepared with hexagonal or spherical Ag NP, with both keratinocytes and fibroblasts having normal or moderately enhanced growth on films containing hexagonally-shaped nanoparticles.
壳聚糖膜与六方银纳米粒子（Ag NP）合成。Ag NP 的独特形状和尺寸将光吸收转移到红外区。用红外光刺激纳米颗粒产生热量，促进荧光标记的葡聚糖分子的细胞内传递。用六方或球形 Ag NP 制备的壳聚糖膜通过光学和热分析以及 X 射线衍射进行了表征。发现壳聚糖分子链与 Ag NP 的界面之间存在细微差异，这取决于纳米粒子的形状。用六方或球形 Ag NP 制备的壳聚糖膜对与皮肤伤口愈合相关的细胞的活力进行了评估，结果表明，含有六方形状纳米颗粒的膜上的角蛋白细胞和成纤维细胞的生长正常或适度增强。
