Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Department of Dermatology, Oslo University Hospital, Oslo, Norway.
Br J Dermatol. 2016 Jul;175(1):95-101. doi: 10.1111/bjd.14537. Epub 2016 Jun 9.
Epidemiological data and the effect of sun exposure on atopic eczema (AE) suggest that vitamin D (vitD) may be involved in the pathogenesis.
To investigate if vitD levels were associated with the presence or severity of AE in the first 2 years of life in children living in south-east Norway.
Infants, recruited to a clinical trial on acute bronchiolitis (n = 404) and from the general population (n = 240), were examined at 1-13 months (first visit) and at 2 years of age (second visit). Caregivers were interviewed using a structured questionnaire. AE was diagnosed clinically, based on well-established criteria. Disease severity was assessed using the SCORing Atopic Dermatitis index. Blood samples were taken for vitD measurements, using liquid chromatography-tandem mass spectrometry and for common filaggrin mutation analyses. Complete data on AE and vitD were available in 596 and 449 children at the first and second visit, respectively.
Atopic eczema was diagnosed in 67 children (11%) at the first visit and in 103 children (23%) at the second. Mean vitD levels were 58·2 nmol L(-1) at the first visit and 66·9 nmol L(-1) at the second. Using vitD level tertiles in multivariate regression analysis, there was no association between vitD levels and AE at either visit, regardless of filaggrin mutation. In children without AE at the first visit, vitD levels did not predict AE at the second.
In this cohort of young children in Norway, we found no association between vitD levels and the presence or severity of AE.
流行病学数据和阳光暴露对特应性皮炎（AE）的影响表明，维生素 D（vitD）可能参与其发病机制。
研究居住在挪威东南部的儿童在生命的头 2 年内，vitD 水平是否与 AE 的存在或严重程度相关。
招募了参加急性细支气管炎临床试验的婴儿（n=404）和一般人群中的婴儿（n=240），在 1-13 个月（第一次就诊）和 2 岁时（第二次就诊）进行检查。通过结构化问卷对照顾者进行访谈。根据既定标准，临床诊断 AE。使用 SCORing Atopic Dermatitis 指数评估疾病严重程度。通过液相色谱-串联质谱法和常见的 filaggrin 突变分析采集血液样本以测量 vitD。在第一次和第二次就诊时，分别有 596 名和 449 名儿童具有完整的 AE 和 vitD 数据。
在第一次就诊时，67 名儿童（11%）被诊断为特应性皮炎，在第二次就诊时，103 名儿童（23%）被诊断为特应性皮炎。第一次就诊时的平均 vitD 水平为 58.2 nmol/L，第二次就诊时为 66.9 nmol/L。在多变量回归分析中，使用 vitD 水平三分位数，无论 filaggrin 突变如何，vitD 水平与两次就诊时的 AE 均无关联。在第一次就诊时没有 AE 的儿童中，vitD 水平不能预测第二次就诊时的 AE。
在挪威的这个幼儿队列中，我们未发现 vitD 水平与 AE 的存在或严重程度之间存在关联。
