Laboratory of Cardiorespiratory and Metabolic Physiology, Federal University of Uberlândia, Uberlândia-MG 38400-678, Brazil.
Laboratory of Immunotechnology and Immunochemistry, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia-MG 38400-902, Brazil.
Nutrients. 2018 Mar 29;10(4):424. doi: 10.3390/nu10040424.
This study tested the effect of isoflavone supplementation in addition to combined exercise training on plasma lipid levels, inflammatory markers and oxidative stress in postmenopausal women. Thirty-two healthy and non-obese postmenopausal women without hormone therapy were randomly assigned to exercise + placebo (PLA; = 15) or exercise + isoflavone supplementation (ISO; = 17) groups. They performed 30 sessions of combined exercises (aerobic plus resistance) over ten weeks and consumed 100 mg of isoflavone supplementation or placebo. Blood samples were collected after an overnight fast to analyze the lipid profile, interleukin-6 (IL-6), interleukin-8 (IL-8), superoxide dismutase (SOD), total antioxidant capacity (FRAP), and thiobarbituric acid reactive substances (TBARS), before and after ten weeks of the intervention. There were no differences in the changes (pre vs. post) between groups for any of the inflammatory markers, oxidative stress markers or lipid profile variables. However, interleukin-8 was different between pre- and post-tests ( < 0.001) in both groups (Δ = 7.61 and 5.61 pg/mL) as were cholesterol levels ( < 0.05), with no interaction between groups. The combination of isoflavone supplementation and exercise training did not alter oxidative stress markers in postmenopausal women, but exercise training alone may increase IL-8 and decrease total cholesterol levels.
本研究旨在测试在联合运动训练的基础上补充异黄酮对绝经后妇女的血浆脂质水平、炎症标志物和氧化应激的影响。将 32 名健康且非肥胖的绝经后妇女（未接受激素治疗）随机分为运动+安慰剂（PLA；n=15）或运动+异黄酮补充剂（ISO；n=17）组。她们在十周内进行了 30 次联合运动（有氧运动加抗阻运动），并摄入 100mg 的异黄酮补充剂或安慰剂。在干预前和十周后，采集禁食过夜后的血液样本，以分析血脂谱、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、超氧化物歧化酶（SOD）、总抗氧化能力（FRAP）和硫代巴比妥酸反应物质（TBARS）。然而，两组的炎症标志物、氧化应激标志物或血脂谱变量的变化（前后）之间没有差异。然而，两组的白细胞介素-8在前后测试之间存在差异（<0.001）（Δ=7.61 和 5.61 pg/mL），胆固醇水平也存在差异（<0.05），但组间无交互作用。异黄酮补充和运动训练的结合并不能改变绝经后妇女的氧化应激标志物，但单独的运动训练可能会增加白细胞介素-8并降低总胆固醇水平。
