儿童HIV感染：治愈的可能性。
Paediatric HIV infection: the potential for cure.
作者信息
Goulder Philip J, Lewin Sharon R, Leitman Ellen M
机构信息
Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK.
The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne 3000, Australia.
出版信息
Nat Rev Immunol. 2016 Apr;16(4):259-71. doi: 10.1038/nri.2016.19. Epub 2016 Mar 14.
Abstract
Recent anecdotal reports of HIV-infected children who received early antiretroviral therapy (ART) and showed sustained control of viral replication even after ART discontinuation have raised the question of whether there is greater intrinsic potential for HIV remission, or even eradication ('cure'), in paediatric infection than in adult infection. This Review describes the influence of early initiation of ART, of immune ontogeny and of maternal factors on the potential for HIV cure in children and discusses the unique immunotherapeutic opportunities and obstacles that paediatric infection may present.
摘要
最近有一些轶事报道称，感染艾滋病毒的儿童接受了早期抗逆转录病毒疗法（ART），即使在停止抗逆转录病毒疗法后仍能持续控制病毒复制，这引发了一个问题：与成人感染相比，儿童感染中艾滋病毒缓解甚至根除（“治愈”）的内在潜力是否更大。本综述描述了早期开始抗逆转录病毒疗法、免疫个体发育和母体因素对儿童艾滋病毒治愈潜力的影响，并讨论了儿童感染可能带来的独特免疫治疗机会和障碍。
相似文献
1
Paediatric HIV infection: the potential for cure.儿童HIV感染：治愈的可能性。
Nat Rev Immunol. 2016 Apr;16(4):259-71. doi: 10.1038/nri.2016.19. Epub 2016 Mar 14.
2
Anti-retroviral therapy failure in HIV-1 infected pregnant women and its associated risk of HIV transmission.抗逆转录病毒疗法治疗失败与 HIV-1 感染孕妇母婴传播的风险。
Arch Gynecol Obstet. 2020 Nov;302(5):1229-1235. doi: 10.1007/s00404-020-05743-8. Epub 2020 Aug 14.
4
Antiretroviral therapy (ART) for treating HIV infection in ART-eligible pregnant women.用于治疗符合抗逆转录病毒治疗条件的孕妇艾滋病毒感染的抗逆转录病毒疗法。
Cochrane Database Syst Rev. 2010 Mar 17(3):CD008440. doi: 10.1002/14651858.CD008440.
5
Maternal and infant factors and lymphocyte, CD4 and CD8 cell counts in uninfected children of HIV-1-infected mothers.HIV-1感染母亲的未感染儿童的母婴因素及淋巴细胞、CD4和CD8细胞计数
AIDS. 2005 Jul 1;19(10):1071-9. doi: 10.1097/01.aids.0000174454.63250.22.
6
British HIV Association guidelines for the management of HIV infection in pregnant women 2012 (2014 interim review).英国艾滋病协会2012年孕妇HIV感染管理指南（2014年中期审查）
HIV Med. 2014 Sep;15 Suppl 4:1-77. doi: 10.1111/hiv.12185.
7
The effect of prenatal highly active antiretroviral therapy on the transmission of congenital and perinatal/early postnatal cytomegalovirus among HIV-infected and HIV-exposed infants.产前高效抗逆转录病毒疗法对 HIV 感染和 HIV 暴露婴儿先天性和围产期/早产后巨细胞病毒传播的影响。
Clin Infect Dis. 2012 Sep;55(6):877-84. doi: 10.1093/cid/cis535. Epub 2012 Jun 6.
8
Successful prevention of HIV mother-to-child transmission with dolutegravir-based combination antiretroviral therapy in a vertically infected pregnant woman with multiclass highly drug-resistant HIV-1.基于多替拉韦的联合抗逆转录病毒疗法成功预防了一名感染多种高度耐药HIV-1的垂直感染孕妇的母婴传播。
AIDS. 2015 Nov 28;29(18):2534-7. doi: 10.1097/QAD.0000000000000888.
9
Prevention of perinatal HIV transmission during pregnancy.孕期预防围产期HIV传播。
J Antimicrob Chemother. 2000 Nov;46(5):657-68. doi: 10.1093/jac/46.5.657.
10
Unexpected vertical transmission of HIV infection.HIV感染的意外垂直传播。
Eur J Pediatr. 2014 Jan;173(1):121-3. doi: 10.1007/s00431-013-2020-9. Epub 2013 May 8.
引用本文的文献
1
Impact of Delayed Early Antiretroviral Therapy Initiation on Treatment Outcomes in Infant Macaques Exposed to SHIVAD8.延迟早期抗逆转录病毒治疗起始对暴露于SHIVAD8的幼年猕猴治疗结果的影响
Viruses. 2025 Jun 14;17(6):849. doi: 10.3390/v17060849.
2
The Complex Role of CD8+ T Cells in Placental HIV Infection.CD8+ T细胞在胎盘HIV感染中的复杂作用
Eur J Immunol. 2025 Jun;55(6):e51615. doi: 10.1002/eji.202451615.
3
Intact HIV DNA decays in children with and without complete viral load suppression.在病毒载量完全抑制和未完全抑制的儿童中，完整的HIV DNA都会衰减。
PLoS Pathog. 2025 Apr 4;21(4):e1013003. doi: 10.1371/journal.ppat.1013003. eCollection 2025 Apr.
4
Autovaccination revisited: potential to boost antiviral immunity and facilitate HIV-1 cure/remission in children.重新审视自体疫苗接种：增强抗病毒免疫力并促进儿童HIV-1治愈/缓解的潜力。
Curr Opin HIV AIDS. 2025 May 1;20(3):271-278. doi: 10.1097/COH.0000000000000924. Epub 2025 Mar 19.
5
Divergent populations of HIV-infected naive and memory CD4+ T cell clones in children on antiretroviral therapy.接受抗逆转录病毒治疗的儿童中，HIV感染的初始和记忆CD4 + T细胞克隆的不同群体。
J Clin Invest. 2025 Mar 6;135(9). doi: 10.1172/JCI188533. eCollection 2025 May 1.
6
Human models that inform antiretroviral therapy-free remission with perinatally acquired HIV infection.为围产期获得性HIV感染的无抗逆转录病毒治疗缓解提供信息的人体模型。
Curr Opin HIV AIDS. 2025 May 1;20(3):249-256. doi: 10.1097/COH.0000000000000918. Epub 2025 Mar 19.
7
Long-term non-progression in children with HIV: estimates from international cohort data.感染艾滋病毒儿童的长期病情无进展：来自国际队列数据的估计
AIDS. 2025 May 1;39(6):746-759. doi: 10.1097/QAD.0000000000004136. Epub 2025 Feb 4.
8
Interventions during Early Infection: Opening a Window for an HIV Cure?早期感染期的干预措施：为 HIV 治愈打开一扇窗？
Viruses. 2024 Oct 9;16(10):1588. doi: 10.3390/v16101588.
9
Assessing the impact of autologous virus neutralizing antibodies on viral rebound time in postnatally SHIV-infected ART-treated infant rhesus macaques.评估自体病毒中和抗体对后天感染 SHIV 的接受 ART 治疗的婴儿恒河猴病毒反弹时间的影响。
Epidemics. 2024 Sep;48:100780. doi: 10.1016/j.epidem.2024.100780. Epub 2024 Jun 27.
10
Sustained aviremia despite anti-retroviral therapy non-adherence in male children after in utero HIV transmission.尽管在 HIV 宫内传播后男性儿童未坚持抗逆转录病毒治疗，但仍持续出现病毒血症。
Nat Med. 2024 Oct;30(10):2796-2804. doi: 10.1038/s41591-024-03105-4. Epub 2024 Jun 6.
本文引用的文献
1
HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report.一名经母婴垂直传播感染 HIV-1 的青少年在中断早期抗逆转录病毒治疗 12 年以上后达到病毒学缓解：法国 ANRS EPF-CO10 儿科队列的 1 例报告。
Lancet HIV. 2016 Jan;3(1):e49-54. doi: 10.1016/S2352-3018(15)00232-5. Epub 2015 Dec 9.
2
Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study.短期服用双硫仑逆转潜伏性 HIV 感染：一项 2 期剂量递增研究。
Lancet HIV. 2015 Dec;2(12):e520-9. doi: 10.1016/S2352-3018(15)00226-X. Epub 2015 Nov 17.
3
Blood-Derived CD4 T Cells Naturally Resist Pyroptosis during Abortive HIV-1 Infection.血液来源的CD4 T细胞在HIV-1感染流产期间天然抵抗细胞焦亡。
Cell Host Microbe. 2015 Oct 14;18(4):463-70. doi: 10.1016/j.chom.2015.09.010.
4
Immunological biomarkers predict HIV-1 viral rebound after treatment interruption.免疫生物标志物可预测治疗中断后HIV-1病毒反弹。
Nat Commun. 2015 Oct 9;6:8495. doi: 10.1038/ncomms9495.
5
Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial.泊马度胺，一种组蛋白去乙酰化酶抑制剂，用于抑制性抗逆转录病毒治疗的 HIV 感染患者潜伏病毒的再激活：一项 1/2 期、单组、临床试验。
Lancet HIV. 2014 Oct;1(1):e13-21. doi: 10.1016/S2352-3018(14)70014-1. Epub 2014 Sep 15.
6
Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection.脂肪组织是慢性HIV和SIV感染期间被忽视的病毒储存库和炎症部位。
PLoS Pathog. 2015 Sep 24;11(9):e1005153. doi: 10.1371/journal.ppat.1005153. eCollection 2015 Sep.
7
The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo.缩肽类药物罗米地辛可在体内逆转HIV-1潜伏感染。
PLoS Pathog. 2015 Sep 17;11(9):e1005142. doi: 10.1371/journal.ppat.1005142. eCollection 2015 Sep.
8
Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.超急性HIV感染期间CD8 + T细胞活化的程度和动力学影响病毒载量设定值。
Immunity. 2015 Sep 15;43(3):591-604. doi: 10.1016/j.immuni.2015.08.012. Epub 2015 Sep 8.
9
CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies.脑源性HIV-1毒株中的中枢神经系统特异性调控元件影响对潜伏逆转剂的反应，对治愈策略具有重要意义。
Mol Psychiatry. 2016 Apr;21(4):574-84. doi: 10.1038/mp.2015.111. Epub 2015 Aug 25.
10
Cell-Associated HIV-1 DNA and RNA Decay Dynamics During Early Combination Antiretroviral Therapy in HIV-1-Infected Infants.HIV-1感染婴儿早期联合抗逆转录病毒治疗期间细胞相关HIV-1 DNA和RNA的衰减动力学
Clin Infect Dis. 2015 Dec 15;61(12):1862-70. doi: 10.1093/cid/civ688. Epub 2015 Aug 13.
Zotero 插件