Goulder Philip J, Lewin Sharon R, Leitman Ellen M
Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK.
The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne 3000, Australia.
Nat Rev Immunol. 2016 Apr;16(4):259-71. doi: 10.1038/nri.2016.19. Epub 2016 Mar 14.
Recent anecdotal reports of HIV-infected children who received early antiretroviral therapy (ART) and showed sustained control of viral replication even after ART discontinuation have raised the question of whether there is greater intrinsic potential for HIV remission, or even eradication ('cure'), in paediatric infection than in adult infection. This Review describes the influence of early initiation of ART, of immune ontogeny and of maternal factors on the potential for HIV cure in children and discusses the unique immunotherapeutic opportunities and obstacles that paediatric infection may present.
最近有一些轶事报道称，感染艾滋病毒的儿童接受了早期抗逆转录病毒疗法（ART），即使在停止抗逆转录病毒疗法后仍能持续控制病毒复制，这引发了一个问题：与成人感染相比，儿童感染中艾滋病毒缓解甚至根除（“治愈”）的内在潜力是否更大。本综述描述了早期开始抗逆转录病毒疗法、免疫个体发育和母体因素对儿童艾滋病毒治愈潜力的影响，并讨论了儿童感染可能带来的独特免疫治疗机会和障碍。
