笑是最好的良药？一项针对日本老年成年人心血管疾病的横断面研究。
Laughter is the Best Medicine? A Cross-Sectional Study of Cardiovascular Disease Among Older Japanese Adults.
作者信息
Hayashi Kei, Kawachi Ichiro, Ohira Tetsuya, Kondo Katsunori, Shirai Kokoro, Kondo Naoki
机构信息
Faculty of Medicine, the University of Tokyo.
出版信息
J Epidemiol. 2016 Oct 5;26(10):546-552. doi: 10.2188/jea.JE20150196. Epub 2016 Mar 12.
BACKGROUND
We sought to evaluate the associations between frequency of daily laughter with heart disease and stroke among community-dwelling older Japanese women and men.
METHODS
We analyzed cross-sectional data in 20 934 individuals (10 206 men and 10 728 women) aged 65 years or older, who participated in the Japan Gerontological Evaluation Study in 2013. In the mail-in survey, participants provided information on daily frequency of laughter, as well as body mass index, demographic and lifestyle factors, and diagnoses of cardiovascular disease, hyperlipidemia, hypertension, and depression.
RESULTS
Even after adjustment for hyperlipidemia, hypertension, depression, body mass index, and other risk factors, the prevalence of heart diseases among those who never or almost never laughed was 1.21 (95% CI, -1.03-1.41) times higher than those who reported laughing every day. The adjusted prevalence ratio for stroke was 1.60 (95% CI, 1.24-2.06).
CONCLUSIONS
Daily frequency of laughter is associated with lower prevalence of cardiovascular diseases. The association could not be explained by confounding factors, such as depressive symptoms.
背景
我们试图评估日本社区居住的老年男性和女性中每日笑的频率与心脏病和中风之间的关联。
方法
我们分析了20934名年龄在65岁及以上的个体（10206名男性和10728名女性）的横断面数据，这些个体参与了2013年的日本老年学评估研究。在邮寄调查中，参与者提供了每日笑的频率信息，以及体重指数、人口统计学和生活方式因素，以及心血管疾病、高脂血症、高血压和抑郁症的诊断信息。
结果
即使在对高脂血症、高血压、抑郁症、体重指数和其他风险因素进行调整后，从不或几乎从不笑的人中心脏病的患病率比每天都笑的人高1.21（95%可信区间，-1.03-1.41）倍。中风的调整患病率比为1.60（95%可信区间，1.24-2.06）。
结论
每日笑的频率与心血管疾病的较低患病率相关。这种关联不能用诸如抑郁症状等混杂因素来解释。
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