Schreiber Stefanie, Vogel Jacob, Schwimmer Henry D, Marks Shawn M, Schreiber Frank, Jagust William
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA; Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.
Neurobiol Aging. 2016 Apr;40:164-172. doi: 10.1016/j.neurobiolaging.2016.01.012. Epub 2016 Jan 30.
Single lifestyle factors affect brain biomarkers and cognition. Here, we addressed the covariance of various lifestyle elements and investigated their impact on positron emission tomography-based β-amyloid (Aβ), hippocampal volume, and cognitive function in aged controls. Lower Aβ burden was associated with a lifestyle comprising high cognitive engagement and low vascular risk, particularly in apolipoprotein E ε4 carriers. Although cognitive function was related to high lifetime cognitive engagement and low vascular risk, Aβ load had no relation to current cognitive function. The covariance between high adult socioeconomic status, high education, and low smoking prevalence predicted better cognitive function and this was mediated by larger hippocampal volume. Our data show that lifestyle is a complex construct composed of associated variables, some of which reflect factors operating over the life span and others which may be developmental. These factors affect brain health via different pathways, which may reinforce one another. Our findings moreover support the importance of an intellectually enriched lifestyle accompanied by vascular health on both cognition and presumed cerebral mediators of cognitive function.
单一生活方式因素会影响脑生物标志物和认知。在此，我们探讨了各种生活方式要素的协方差，并研究了它们对老年对照组中基于正电子发射断层扫描的β-淀粉样蛋白（Aβ）、海马体积和认知功能的影响。较低的Aβ负担与包含高认知参与度和低血管风险的生活方式相关，尤其是在载脂蛋白Eε4携带者中。虽然认知功能与高终身认知参与度和低血管风险有关，但Aβ负荷与当前认知功能无关。高成人社会经济地位、高教育水平和低吸烟率之间的协方差预示着更好的认知功能，这是由更大的海马体积介导的。我们的数据表明，生活方式是一个由相关变量组成的复杂结构，其中一些反映了在整个生命周期中起作用的因素，而另一些可能是发育性的。这些因素通过不同途径影响大脑健康，这些途径可能相互强化。此外，我们的研究结果支持了丰富的智力生活方式与血管健康对认知和认知功能假定的脑介质的重要性。
