Shandong Normal University, Jinan, 250014, China.
Shandong Institute of Prevention and Control for Endemic Disease, Jinan, 250014, China.
Biol Trace Elem Res. 2022 Jun;200(6):2581-2587. doi: 10.1007/s12011-021-02872-2. Epub 2021 Aug 31.
Iodine excess typically affects thyroid function in the human body and may damage carotid artery. Four investigation plots with different water iodine levels were selected in Shandong Province, China. These included a low, medium, and high iodine group and an iodine excess group whose water iodine content was < 10, 50-150, 150-300, and > 300 μg/L, respectively. Residents aged 20-65 years answered a questionnaire and underwent carotid artery ultrasonography, and their height, weight, and urinary iodine concentrations were measured. A total of 2026 individuals participated in the study. Urinary iodine concentration increased with increased water iodine levels. The medial thickening rate and intimal roughness rate in the iodine excess group were significantly higher than in the other three groups. After controlling for factors such as gender, age, and BMI, iodine excess remained as a risk factor for carotid intima-media thickening. Excess water iodine in the external environment is a risk factor for intima-media thickening of the carotid artery, suggesting that iodine excess may cause vascular injury and promote atherosclerosis.
碘过量通常会影响人体甲状腺功能，并可能损害颈动脉。在中国山东省选择了四个具有不同水碘水平的调查点，包括低碘、中碘、高碘和碘过量组，其水碘含量分别为<10、50-150、150-300 和>300μg/L。年龄在 20-65 岁的居民回答了一份问卷，并接受了颈动脉超声检查，测量了他们的身高、体重和尿碘浓度。共有 2026 人参与了这项研究。尿碘浓度随水碘水平的升高而升高。碘过量组的中层增厚率和内膜粗糙度率明显高于其他三组。在控制性别、年龄和 BMI 等因素后，碘过量仍然是颈动脉内膜中层增厚的危险因素。外环境中过多的水碘是颈动脉内膜中层增厚的危险因素，提示碘过量可能导致血管损伤并促进动脉粥样硬化。
