Nawaz Muhammad, Fatima Farah, Nazarenko Irina, Ekström Karin, Murtaza Iram, Anees Mariam, Sultan Aneesa, Neder Luciano, Camussi Giovanni, Valadi Hadi, Squire Jeremy A, Kislinger Thomas
a Department of Pathology and Forensic Medicine, Ribeirao Preto School of Medicine , University of Sao Paulo , Sao Paulo , Brazil.
b Department of Rheumatology and Inflammation Research , Sahlgrenska Academy at the University of Gothenburg , Guldhedsgatan Sweden.
Expert Rev Proteomics. 2016;13(4):395-409. doi: 10.1586/14789450.2016.1165613.
In recent years there has been tremendous interest in both the basic biology and applications of extracellular vesicles (EVs) in translational cancer research. This includes a better understanding of their biogenesis and mechanisms of selective cargo packaging, their precise roles in horizontal communication, and their application as non-invasive biomarkers. The rapid advances in next-generation omics technologies are the driving forces for these discoveries. In this review, the authors focus on recent results of EV research in ovarian cancer. A deeper understanding of ovarian cancer-derived EVs, the types of cargo molecules and their biological roles in cancer growth, metastases and drug resistance, could have significant impact on the discovery of novel biomarkers and innovative therapeutics. Insights into the role of EVs in immune regulation could lead to novel approaches built on EV-based immunotherapy.
近年来，细胞外囊泡（EVs）的基础生物学及其在转化癌症研究中的应用引发了极大的关注。这包括对其生物发生和选择性货物包装机制的更好理解、它们在横向通讯中的精确作用以及作为非侵入性生物标志物的应用。下一代组学技术的快速发展是这些发现的驱动力。在这篇综述中，作者重点关注了EVs在卵巢癌研究中的最新成果。对卵巢癌来源的EVs、货物分子类型及其在癌症生长、转移和耐药性中的生物学作用有更深入的了解，可能会对新型生物标志物的发现和创新疗法产生重大影响。对EVs在免疫调节中作用的深入了解可能会催生基于EVs免疫疗法的新方法。
