迷迭香酸、木犀草素及其硫酸化衍生物的生物活性与治疗作用机制
[Biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulphated derivatives].
作者信息
Popov A M, Krivoshapko O N, Klimovich A A, Artyukov A A
机构信息
Elyakov Pacibic Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia; Far Eastern Federal University, Vladivostok, Russia.
Elyakov Pacibic Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia.
出版信息
Biomed Khim. 2016 Jan-Feb;62(1):22-30. doi: 10.18097/PBMC20166201022.
The review considers recent experimental studies of biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives in diseases associated with disorders of carbohydrate and lipid metabolism. Particular attention is focused on the results of studies showing a high therapeutic potential of these phenolic compounds in their prophylactic and therapeutic use at experimental modeling of type 2 diabetes and hyperlipidemia. Based on the analysis of our results and the literature data putative mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives have been proposed.
该综述探讨了迷迭香酸、木犀草素及其硫酸化衍生物在与碳水化合物和脂质代谢紊乱相关疾病中的生物活性及治疗作用机制的近期实验研究。特别关注了那些表明这些酚类化合物在2型糖尿病和高脂血症实验模型中的预防和治疗应用具有高治疗潜力的研究结果。基于对我们的研究结果和文献数据的分析，提出了迷迭香酸、木犀草素及其硫酸化衍生物治疗作用的假定机制。
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