大叶藻属海草多酚复合物的主要成分、其抗糖尿病特性及作用机制。
Main constituents of polyphenol complex from seagrasses of the genus Zostera, their antidiabetic properties and mechanisms of action.
作者信息
Styshova Olga Nikolaevna, Popov Alexander Michailovich, Artyukov Alexander Alekseevish, Klimovich Anna Anatolievna
机构信息
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690022, Russia.
School of Natural Sciences, Far Eastern Federal University, Vladivostok 690000, Russia.
出版信息
Exp Ther Med. 2017 May;13(5):1651-1659. doi: 10.3892/etm.2017.4217. Epub 2017 Mar 10.
Abstract
The present review analyzed the recent experimental studies of the alleviating activity of main constituents of the polyphenol complex from seagrasses of the genus , namely rosmarinic acid, luteolin and its sulfated derivatives, on carbohydrate and lipid metabolism disorders. A number of studies by our group and others, in which various experimental models of diabetes and hyperlipidemia were used, show a therapeutic action of the polyphenol complex and the abovementioned phenolic constituents, when applied separately and in combination. Based on the analysis of the results of these studies, the probable mechanisms of the therapeutic action of these compounds in diabetes and hyperlipidemia were proposed.
摘要
本综述分析了海草属多酚复合物主要成分，即迷迭香酸、木犀草素及其硫酸化衍生物，对碳水化合物和脂质代谢紊乱的缓解活性的近期实验研究。我们小组和其他小组的多项研究使用了各种糖尿病和高脂血症实验模型，结果表明，多酚复合物和上述酚类成分单独应用或联合应用时均具有治疗作用。基于对这些研究结果的分析，提出了这些化合物在糖尿病和高脂血症中治疗作用的可能机制。
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