Luo Cheng, Zhang Xingxing, Cao Xinyi, Gan Yulong, Li Ting, Cheng Yan, Cao Weifang, Jiang Lijuan, Yao Dezhong, Li Chunbo
Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine Shanghai, China.
Front Aging Neurosci. 2016 Mar 3;8:32. doi: 10.3389/fnagi.2016.00032. eCollection 2016.
Lateralization of function is an important organization of the human brain. The distribution of intrinsic networks in the resting brain is strongly related to cognitive function, gender and age. In this study, a longitudinal design with 1 year's duration was used to evaluate the cognitive training effects on the lateralization of intrinsic networks among healthy older adults. The subjects were divided into two groups randomly: one with multi-domain cognitive training over 3 months and the other as a wait-list control group. Resting state fMRI data were acquired before training and 1 year after training. We analyzed the functional lateralization in 10 common resting state fMRI networks. We observed statically significant training effects on the lateralization of two important RSNs related to high-level cognition: right- and left- frontoparietal networks (FPNs). The lateralization of the left-FPN was retained especially well in the training group but decreased in the control group. The increased lateralization with aging was observed in the cerebellum network (CereN), in which the lateralization was significantly increased in the control group, although the same change tendency was observed in the training group. These findings indicate that the lateralization of the high-level cognitive intrinsic networks is sensitive to multi-domain cognitive training. This study provides neuroimaging evidence to support the hypothesis that cognitive training should have an advantage in preventing cognitive decline in healthy older adults.
功能偏侧化是人类大脑的一种重要组织形式。静息状态下大脑内在网络的分布与认知功能、性别和年龄密切相关。在本研究中，采用为期1年的纵向设计来评估认知训练对健康老年人内在网络偏侧化的影响。受试者被随机分为两组：一组接受为期3个月的多领域认知训练，另一组作为候补对照组。在训练前和训练后1年采集静息态功能磁共振成像（fMRI）数据。我们分析了10个常见静息态fMRI网络中的功能偏侧化情况。我们观察到，对于与高级认知相关的两个重要静息态网络（RSNs）的偏侧化，训练产生了具有统计学意义的显著效果：右侧和左侧额顶叶网络（FPNs）。训练组中左侧FPN的偏侧化保持得特别好，而对照组中则有所下降。在小脑网络（CereN）中观察到随着年龄增长偏侧化增加，其中对照组的偏侧化显著增加，尽管训练组也观察到相同的变化趋势。这些发现表明，高级认知内在网络的偏侧化对多领域认知训练敏感。本研究提供了神经影像学证据，以支持认知训练在预防健康老年人认知衰退方面应具有优势这一假设。
