1 Integrated Cancer Genomics Division, Translational Genomics Research Institute , Phoenix, Arizona.
2 Hyundai Cancer Genomics Center, Children's Hospital of Orange County , Orange, California.
J Adolesc Young Adult Oncol. 2016 Sep;5(3):297-302. doi: 10.1089/jayao.2015.0068. Epub 2016 Mar 14.
Glassy cell carcinoma of the cervix (GCCC) is a very rare and aggressive form of cervical cancer. An adolescent female with advanced metastatic disease was enrolled in our genomic profiling research protocol. We identified high-level amplification of epidermal growth factor receptor (EGFR) and Yes-associated protein-1 (YAP1), which led to the addition of EGFR inhibitors to the chemotherapy regimen. Here, we report the first genetically profiled case of GCCC with potential therapeutic implications.
宫颈玻璃样细胞癌（GCCC）是一种非常罕见且侵袭性强的宫颈癌。一名患有晚期转移性疾病的青少年女性被纳入我们的基因组分析研究方案。我们发现表皮生长因子受体（EGFR）和 Yes 相关蛋白-1（YAP1）的高水平扩增，这导致在化疗方案中加入了 EGFR 抑制剂。在此，我们报告首例具有潜在治疗意义的 GCCC 的基因分析病例。
