Richard Tenazoa-Villalobos José, Fermín Yan-Quiroz Edgar, Augusto Ordoñez-Chinguel, Leonor Prado-Cucho Sofia, Isac Miranda-Narro Adesman, Villoslada-Terrones Vladimir
Oncologic Surgery Area of the Víctor Lazarte Echegaray Hospital - EsSalud, Trujillo13013, Peru.
School of Medicine, Universidad Privada Antenor Orrego, Trujillo 13008, Peru.
Ecancermedicalscience. 2025 Feb 6;19:1842. doi: 10.3332/ecancer.2025.1842. eCollection 2025.
Glassy cell carcinoma is an extremely rare entity that occurs in 1% to 2% of all cases of cervical cancer, affects young women with greater predisposition, is related to poor prognosis, and distant metastasis. It correlates strongly with the presence of high-risk human papillomavirus (serotypes 16, 18 and 31) and histologically manifests as ground-glass cells, cytosol with vast granular and dense chromatin with large nuclei and protruding nucleoli. We present a 51-year-old woman who was diagnosed with glassy cell carcinoma of the cervix (before the latest edition of the World Health Organisation classification of tumours) in FIGO stage IB1 that was managed with radical hysterectomy and bilateral pelvic lymph node dissection, whose pathological result shows infiltration of the upper third of the vagina, changing the staging to FIGO IIA-1. She received adjuvant concurrent radiotherapy/chemotherapy with a good response, subsequent controls without signs of recurrence and remained currently alive.
玻璃样细胞癌是一种极其罕见的疾病，在所有宫颈癌病例中占1%至2%，更易发生于年轻女性，与预后不良及远处转移有关。它与高危型人乳头瘤病毒（血清型16、18和31）的存在密切相关，组织学上表现为毛玻璃样细胞，胞质内有大量颗粒和致密染色质，细胞核大且核仁突出。我们报告一名51岁女性，在世界卫生组织肿瘤分类最新版之前被诊断为宫颈玻璃样细胞癌，国际妇产科联盟（FIGO）分期为IB1期，接受了根治性子宫切除术和双侧盆腔淋巴结清扫术，其病理结果显示阴道上三分之一受侵，分期变为FIGO IIA-1期。她接受了辅助同步放化疗，反应良好，随后的复查未发现复发迹象，目前仍然存活。
