短链脂肪酸乙酸盐对肝脏脂肪堆积的重编程及脂肪组织的“褐变”
Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate.
作者信息
Sahuri-Arisoylu M, Brody L P, Parkinson J R, Parkes H, Navaratnam N, Miller A D, Thomas E L, Frost G, Bell J D
机构信息
Department of Life Sciences, Faculty of Science and Technology, University of Westminster, London, UK.
Nutrition and Dietetic Research Group, Division of Diabetes, Endocrinology and Metabolism, Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
出版信息
Int J Obes (Lond). 2016 Jun;40(6):955-63. doi: 10.1038/ijo.2016.23. Epub 2016 Feb 12.
BACKGROUND/OBJECTIVES: Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight and adiposity. However, determining the contribution of central and peripheral mechanisms to these effects has not been possible.
SUBJECTS/METHODS: C57BL/6 mice fed with either normal or high-fat diet were treated with nanoparticle-delivered acetate, and the effects on metabolism were investigated.
RESULTS
In the liver, acetate decreased lipid accumulation and improved hepatic function, as well as increasing mitochondrial efficiency. In white adipose tissue, it inhibited lipolysis and induced 'browning', increasing thermogenic capacity that led to a reduction in body adiposity.
CONCLUSIONS
This study provides novel insights into the peripheral mechanism of action of acetate, independent of central action, including 'browning' and enhancement of hepatic mitochondrial function.
背景/目的：碳水化合物经微生物群发酵产生的短链脂肪酸与食欲降低、体重减轻和肥胖程度减轻有关。然而，确定中枢和外周机制对这些作用的贡献尚无可能。
受试者/方法：给喂食正常或高脂饮食的C57BL/6小鼠用纳米颗粒递送的乙酸盐进行处理，并研究其对代谢的影响。
结果
在肝脏中，乙酸盐减少脂质积累，改善肝功能，并提高线粒体效率。在白色脂肪组织中，它抑制脂肪分解并诱导“褐变”，增加产热能力，从而导致身体肥胖程度降低。
结论
本研究为乙酸盐不依赖中枢作用的外周作用机制提供了新见解，包括“褐变”和增强肝线粒体功能。
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