Zhang Xiao-Rui, Zeng Chao-Mei, Liu Jie
Department of Pediatrics, Peking University People's Hospital, Beijing 100044, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2016 Mar;18(3):195-200. doi: 10.7499/j.issn.1008-8830.2016.03.001.
To study the effect and safety of intensive phototherapy in the treatment of neonatal hyperbilirubinemia.
A total of 144 neonates with neonatal hyperbilirubinemia were randomly and prospectively divided into intensive phototherapy group and conventional phototherapy group, with 72 neonates in each group. The therapeutic effect and incidence of complications were compared between the two groups.
Within 12 hours after phototherapy, the total serum bilirubin level in the intensive phototherapy group was significantly lower than in the conventional phototherapy group (P<0.05), and the intensive phototherapy group had a significantly greater reduction in serum bilirubin level than the conventional phototherapy group (P<0.05). The intensives phototherapy group had a significantly shorter time of phototherapy than the conventional phototherapy group (P<0.05). The incidence rates of fever, diarrhea, rash, and hypocalcemia and reductions in blood calcium and hemoglobin levels after phototherapy showed no significant differences between the two groups.
During the initial stage of phototherapy, intensive phototherapy can quickly and effectively reduce the serum level of bilirubin in neonates with neonatal hyperbilirubinemia. It can also shorten the total phototherapy time, and does not increase the incidence of adverse events. Therefore, it is superior to conventional phototherapy.
研究强化光疗治疗新生儿高胆红素血症的疗效及安全性。
将144例新生儿高胆红素血症患儿随机前瞻性分为强化光疗组和传统光疗组，每组72例。比较两组的治疗效果及并发症发生率。
光疗后12小时内，强化光疗组血清总胆红素水平显著低于传统光疗组（P<0.05），强化光疗组血清胆红素水平下降幅度显著大于传统光疗组（P<0.05）。强化光疗组光疗时间显著短于传统光疗组（P<0.05）。两组光疗后发热、腹泻、皮疹、低钙血症发生率及血钙、血红蛋白水平下降情况比较，差异均无统计学意义。
在光疗初期，强化光疗能快速有效降低新生儿高胆红素血症患儿的血清胆红素水平，还可缩短总光疗时间，且不增加不良事件发生率。因此，强化光疗优于传统光疗。
