Division of Neonatology, Ministry of Health Erzurum Nene Hatun Maternity Hospital, Erzurum, Turkey.
Drug Chem Toxicol. 2013 Jan;36(1):88-92. doi: 10.3109/01480545.2011.653491. Epub 2012 Feb 24.
In this study, we aimed to clarify the following questions: 1) Does phototherapy (PT) cause genotoxicity in full-term newborn babies undergoing PT as a result of neonatal jaundice?, 2) if genotoxic effect occurs, is there any relationship between the duration of PT and genotoxicity?, and 3) is genotoxic effect temporary or not? The frequency of sister chromatid exchange (SCE) was determined in jaundiced newborns before, during, and after phototherapy, then determined again in childhood (approximately 3.5 years old). Mean frequency of SCE of 22 full-term jaundiced babies significantly increased during the PT procedure and in every single day, compared to the previous day, in comparison to the pre-PT basal value (6.20 ± 0.57;); mean SCE frequencies at 24, 48, 72, and 96 hours were 7.75 ± 0.40, 8.16 ± 0.47, 8.50 ± 0.40, and 9.36 ± 0.55, respectively (all P-values <0.01). In childhood, no significant difference was found between the mean SCE value (4.9 ± 0.9) of 20 of 22 children, who received PT in the neonatal period, and the mean SCE value (4.7 ± 0.6) of 20 coevaluated healthy children (P = 0.40). This study demonstrates that the negative effect of PT on SCE is a temporary effect.
在这项研究中，我们旨在澄清以下问题：1）光疗（PT）是否会导致因新生儿黄疸而接受 PT 的足月新生儿产生遗传毒性？2）如果发生遗传毒性效应，PT 持续时间与遗传毒性之间是否存在任何关系？3）遗传毒性效应是否是暂时的？在进行光疗之前、期间和之后，通过确定姐妹染色单体交换（SCE）的频率，在黄疸新生儿中确定了 SCE 的频率，然后在儿童期（大约 3.5 岁）再次确定。与之前的日子相比，22 名足月黄疸婴儿在 PT 过程中以及每一天的 SCE 平均频率都显著增加，与 PT 前的基础值相比（6.20 ± 0.57）；在 24、48、72 和 96 小时的平均 SCE 频率分别为 7.75 ± 0.40、8.16 ± 0.47、8.50 ± 0.40 和 9.36 ± 0.55，所有 P 值均<0.01）。在儿童期，接受过新生儿期 PT 的 22 名儿童中的 20 名的平均 SCE 值（4.9 ± 0.9）与 20 名接受过评估的健康儿童的平均 SCE 值（4.7 ± 0.6）之间无显著差异（P = 0.40）。这项研究表明，PT 对 SCE 的负面影响是暂时的。
