Krishnamurthy S, Gnanasammandhan M K, Xie C, Huang K, Cui M Y, Chan J M
School of Chemical and Biomedical Engineering and Lee Kong Chian School of Medicine, Nanyang Technological University, Block N1.3, #B4-10, 70 Nanyang Drive, Singapore 637457.
Department of Biomedical Engineering, National University of Singapore, 9 Engineering Drive 1, Block EA, #03-12, Singapore 117575.
Nanoscale. 2016 Apr 7;8(13):6981-5. doi: 10.1039/c5nr07588b.
Core-shell type 'nanoghosts' were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h. Doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.
核壳型“纳米幽灵”是由负载药物的可生物降解聚乳酸-羟基乙酸共聚物（PLGA）核和单核细胞膜衍生的壳合成的。纳米幽灵呈单分散状态，平均尺寸小于200nm，在120小时内表现出良好的血清稳定性。与转移性MCF-7乳腺癌细胞系中的未包被纳米颗粒对照相比，负载阿霉素的纳米幽灵表现出更高的细胞摄取率和细胞毒性。
