Jeong Sun Hye, Hong Hyun Sook, Lee Eun Hye, Kwak Jeong Ja
Department of Radiology, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Republic of Korea.
Department of Pathology, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Republic of Korea.
Int J Endocrinol. 2016;2016:2397690. doi: 10.1155/2016/2397690. Epub 2016 Feb 10.
Objectives. We compared the ultrasonography and pathology features of papillary thyroid carcinoma (PTC) in pediatric and adolescents with Hashimoto's thyroiditis (HT) with those of non-HT patients. Materials and Methods. Eleven patients who were surgically confirmed to have pediatric or adolescent PTC from 2006 to 2014 were included in this study. We retrospectively analyzed the preoperative ultrasonography and pathology features of PTC arising in HT and non-HT patients. Results. On ultrasonography, thyroid gland was lobulated and enlarged, with many scattered microcalcifications in four of five HT patients. Four of six non-HT patients had suspicious masses with calcifications. The diffuse sclerosing variant of PTC (DSVPTC) was found in three of five HT patients, but none in non-HT patients. Macroscopic or microscopic extrathyroidal extension was evident in all of the HT patients and four of the non-HT patients. Neck lymph node metastases were in all HT patients and five of non-HT patients. Conclusions. Three of five PTCs in pediatric and adolescent HT patients were DSVPTC, whereas all PTCs of the non-HT patients were classic type. On ultrasonography, thyroid gland was diffusely enlarged with scattered microcalcifications in four of five HT patients. All five HT cases had aggressive disease, including extrathyroidal extension and cervical lymph node metastases.
目的。我们比较了患有桥本甲状腺炎（HT）的儿童和青少年甲状腺乳头状癌（PTC）与非HT患者的超声检查和病理特征。材料与方法。本研究纳入了2006年至2014年手术确诊为儿童或青少年PTC的11例患者。我们回顾性分析了HT患者和非HT患者中PTC的术前超声检查和病理特征。结果。在超声检查中，5例HT患者中有4例甲状腺呈分叶状且肿大，有许多散在的微钙化。6例非HT患者中有4例有可疑肿块伴钙化。5例HT患者中有3例发现PTC弥漫性硬化变异型（DSVPTC），而非HT患者中无一例。所有HT患者及4例非HT患者均有明显的肉眼或镜下甲状腺外侵犯。所有HT患者及5例非HT患者均有颈部淋巴结转移。结论。患有HT的儿童和青少年患者中，5例PTC中有3例为DSVPTC，而非HT患者的所有PTC均为经典型。在超声检查中，5例HT患者中有4例甲状腺弥漫性肿大并有散在微钙化。所有5例HT病例均有侵袭性疾病，包括甲状腺外侵犯和颈部淋巴结转移。
