Yeo Min-Kyung, Bae Ja Seong, Lee Sohee, Kim Min-Hee, Lim Dong-Jun, Lee Youn Soo, Jung Chan Kwon
Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea ; Department of Pathology, Chungnam National University School of Medicine, Daejeon 301-747, Republic of Korea.
Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea.
Int J Endocrinol. 2015;2015:456027. doi: 10.1155/2015/456027. Epub 2015 Apr 23.
Background. The Warthin-like variant of papillary thyroid (WLPTC) is a rare subtype of papillary thyroid carcinoma (PTC) resembling Warthin tumors of the salivary glands. Due to its rarity, the clinicopathologic and molecular features of WLPTC remain unclear. Methods. Of the 2,139 patients who underwent surgical treatment for PTC from 2012 to 2013, 40 patients with WLPTC were identified and compared to 200 consecutive patients with classic PTC. BRAF mutation was tested with pyrosequencing. Results. There were no significant differences in age, predilection for women, multifocality, extrathyroidal extension, or lymph node metastasis between WLPTC and classic PTC. However, WLPTCs were more commonly associated with Hashimoto's thyroiditis than classic PTCs (93% versus 36%, resp., P < 0.001) and showed significantly lower rate of BRAF mutation when compared to classic PTCs (65% versus 84%, resp., P = 0.007). In classic PTC, the frequency of BRAF mutations was negatively correlated with coexisting Hashimoto's thyroiditis. When we compared WLPTC and classic PTC in the patients with coexisting Hashimoto's thyroiditis, there were no significant differences in clinicopathologic characteristics or the BRAF mutational rate between the two groups. Conclusions. Patients with WLPTC have similar demographic, clinical, pathologic, and molecular characteristics to those with classic PTC coexisting with Hashimoto's thyroiditis.
背景。甲状腺乳头状癌的沃辛样变异型（WLPTC）是一种罕见的甲状腺乳头状癌（PTC）亚型，类似于涎腺沃辛瘤。由于其罕见性，WLPTC的临床病理和分子特征仍不清楚。方法。在2012年至2013年接受PTC手术治疗的2139例患者中，识别出40例WLPTC患者，并与200例连续的经典PTC患者进行比较。采用焦磷酸测序检测BRAF突变。结果。WLPTC与经典PTC在年龄、女性偏好、多灶性、甲状腺外扩展或淋巴结转移方面无显著差异。然而，WLPTC比经典PTC更常与桥本甲状腺炎相关（分别为93%和36%，P < 0.001），并且与经典PTC相比，BRAF突变率显著更低（分别为65%和84%，P = 0.007）。在经典PTC中，BRAF突变频率与并存的桥本甲状腺炎呈负相关。当我们比较并存桥本甲状腺炎的患者中的WLPTC和经典PTC时，两组在临床病理特征或BRAF突变率方面无显著差异。结论。WLPTC患者在人口统计学、临床、病理和分子特征方面与并存桥本甲状腺炎的经典PTC患者相似。
