Wang Xin, Zakaria Osama, Madi Marwa, Kasugai Shohei
Department of Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Department of Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Tokyo, Japan; Department of Oral and Maxillofacial Surgery, Pharos University in Alexandria, Alexandria, Egypt.
J Tissue Eng. 2015 Jun 30;6:2041731415592075. doi: 10.1177/2041731415592075. eCollection 2015 Jan-Dec.
This study evaluated the quantity and quality of newly formed vertical bone induced by sputtered hydroxyapatite-coated titanium implants compared with sandblasted acid-etched implants after dura mater elevation. Hydroxyapatite-coated and non-coated implants (n = 20/group) were used and divided equally into two groups. All implants were randomly placed into rabbit calvarial bone (four implants for each animal) emerging from the inferior cortical layer, displacing the dura mater 3 mm below the original bone. Animals were sacrificed at 4 (n = 5) and 8 (n = 5) weeks post-surgery. Vertical bone height and area were analyzed histologically and radiographically below the original bone. Vertical bone formation was observed in both groups. At 4 and 8 weeks, vertical bone height reached a significantly higher level in the hydroxyapatite compared with the non-coated group (p < 0.05). Vertical bone area was significantly larger in the hydroxyapatite compared with the non-coated group at 4 and 8 weeks (p < 0.05). This study indicates that vertical bone formation can be induced by dura mater elevation and sputtered hydroxyapatite coating can enhance vertical bone formation.
本研究评估了在硬脑膜掀起后，与喷砂酸蚀种植体相比，溅射羟基磷灰石涂层钛种植体诱导新形成的垂直骨的数量和质量。使用了羟基磷灰石涂层和未涂层的种植体（每组n = 20），并将其平均分为两组。所有种植体随机植入兔颅骨从皮质下层穿出的部位，将硬脑膜推移至原骨下方3毫米处。在术后4周（n = 5）和8周（n = 5）处死动物。在组织学和影像学上分析原骨下方的垂直骨高度和面积。两组均观察到垂直骨形成。在4周和8周时，与未涂层组相比，羟基磷灰石组的垂直骨高度显著更高（p < 0.05）。在4周和8周时，与未涂层组相比，羟基磷灰石组的垂直骨面积显著更大（p < 0.05）。本研究表明，硬脑膜掀起可诱导垂直骨形成，溅射羟基磷灰石涂层可增强垂直骨形成。
