Johansson Johannes D, Mireles Miguel, Morales-Dalmau Jordi, Farzam Parisa, Martínez-Lozano Mar, Casanovas Oriol, Durduran Turgut
ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Sciences and Technology, 08860, Castelldefels (Barcelona), Spain.
Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology, Bellvitge Biomedical Research Institute-IDIBELL, 08908, L'Hospitalet de Llobregat (Barcelona), Spain.
Biomed Opt Express. 2016 Jan 15;7(2):481-98. doi: 10.1364/BOE.7.000481. eCollection 2016 Feb 1.
A scanning system for small animal imaging using non-contact, hybrid broadband diffuse optical spectroscopy (ncDOS) and diffuse correlation spectroscopy (ncDCS) is presented. The ncDOS uses a two-dimensional spectrophotometer retrieving broadband (610-900 nm) spectral information from up to fifty-seven source-detector distances between 2 and 5 mm. The ncDCS data is simultaneously acquired from four source-detector pairs. The sample is scanned in two dimensions while tracking variations in height. The system has been validated with liquid phantoms, demonstrated in vivo on a human fingertip during an arm cuff occlusion and on a group of mice with xenoimplanted renal cell carcinoma.
本文介绍了一种用于小动物成像的扫描系统，该系统采用非接触式混合宽带漫射光学光谱（ncDOS）和漫射相关光谱（ncDCS）技术。ncDOS使用二维分光光度计，可从2至5毫米之间多达57个源探测器距离处获取宽带（610 - 900纳米）光谱信息。ncDCS数据同时从四对源探测器获取。在跟踪高度变化的同时，对样品进行二维扫描。该系统已通过液体模型验证，并在手臂袖带阻断期间在人体指尖以及在异种移植肾细胞癌的一组小鼠上进行了体内演示。
