通过扩散相关光谱法测量小鼠乳腺癌中化疗药物特异性微血管血流改变。
Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy.
作者信息
Ramirez Gabriel, Proctor Ashley R, Jung Ki Won, Wu Tong Tong, Han Songfeng, Adams Russell R, Ren Jingxuan, Byun Daniel K, Madden Kelley S, Brown Edward B, Foster Thomas H, Farzam Parisa, Durduran Turgut, Choe Regine
机构信息
Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA.
出版信息
Biomed Opt Express. 2016 Aug 24;7(9):3610-3630. doi: 10.1364/BOE.7.003610. eCollection 2016 Sep 1.
Abstract
The non-invasive, measurement of microvascular blood flow has the potential to enhance breast cancer therapy monitoring. Here, longitudinal blood flow of 4T1 murine breast cancer (N=125) under chemotherapy was quantified with diffuse correlation spectroscopy based on layer models. Six different treatment regimens involving doxorubicin, cyclophosphamide, and paclitaxel at clinically relevant doses were investigated. Treatments with cyclophosphamide increased blood flow as early as 3 days after administration, whereas paclitaxel induced a transient blood flow decrease at 1 day after administration. Early blood flow changes correlated strongly with the treatment outcome and distinguished treated from untreated mice individually for effective treatments.
摘要
微血管血流的非侵入性测量具有增强乳腺癌治疗监测的潜力。在此，基于层模型，利用扩散相关光谱法定量分析了化疗下4T1小鼠乳腺癌（N = 125）的纵向血流。研究了六种涉及临床相关剂量的阿霉素、环磷酰胺和紫杉醇的不同治疗方案。环磷酰胺治疗在给药后3天就增加了血流，而紫杉醇在给药后1天引起短暂的血流减少。早期血流变化与治疗结果密切相关，并且能有效区分治疗组和未治疗组的小鼠。
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