Chen Weiting, Wang Xin, Wang Bingyuan, Wang Yihan, Zhang Yanqi, Zhao Huijuan, Gao Feng
Collage of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
Collage of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China; Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China.
Biomed Opt Express. 2016 Jan 15;7(2):499-511. doi: 10.1364/BOE.7.000499. eCollection 2016 Feb 1.
We implemented a novel lock-in photon-counting detection architecture that combines the ultra-high sensitivity of the photon-counting detection and the measurement parallelism of the lock-in technique. Based on this technique, a dual-wavelength simultaneous measurement continuous wave diffuse optical tomography system was developed with a configuration of 16 sources and 16 detectors that works in a tandem serial-to-parallel fashion. Methodology validation and performance assessment of the system were conducted using phantom experiments that demonstrate excellent measurement linearity, moderate-term system stability, robustness to noise and negligible inter-wavelength crosstalk. 2-D imaging experiments further validate high sensitivity of the lock-in photon-counting methodology as well as high reliability of the proposed system. The advanced detection principle can be adapted to achieving a fully parallelized instrumentation for the extended applications.
我们实现了一种新颖的锁相光子计数检测架构，该架构结合了光子计数检测的超高灵敏度和锁相技术的测量并行性。基于此技术，开发了一种双波长同步测量连续波扩散光学层析成像系统，其配置为16个光源和16个探测器，以串联串并方式工作。使用体模实验对该系统进行了方法学验证和性能评估，结果表明该系统具有出色的测量线性、中期系统稳定性、对噪声的鲁棒性以及可忽略不计的波长间串扰。二维成像实验进一步验证了锁相光子计数方法的高灵敏度以及所提出系统的高可靠性。这种先进的检测原理可适用于实现用于扩展应用的完全并行化仪器。
