Miller I, Serchi T, Cambier S, Diepenbroek C, Renaut J, van den Berg J H J, Kwadijk C, Gutleb A C, Rijntjes E, Murk A J
Institute for Medical Biochemistry, Department for Biomedical Sciences, University of Veterinary Medicine Vienna, Veterinaerplatz 1, A-1210 Vienna, Austria.
Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology (LIST), 5, avenue des Hauts-Fourneaux, L-4362 Esch-sur-Alzette, Grand-duchy of Luxembourg.
Data Brief. 2016 Feb 27;7:386-92. doi: 10.1016/j.dib.2016.02.047. eCollection 2016 Jun.
Female Wistar rats with different thyroid status (eu-, hypothyroid) were exposed to 0, 3 or 30 mg/kg body weight of the flame retardant HBCD for 7 days. Changes in protein patterns obtained by 2D-DIGE were evaluated, and different animal groups compared taking into account their exposure and thyroid status. Proteins significantly altered in abundance in any of these comparisons were identified by mass spectrometry. These data, together with hormone data of the animals, are discussed in "Hexa-bromocyclododecane (HBCD) induced changes in the liver proteome of eu- and hypothyroid female rats" (Miller et al., 2016) [1].
将处于不同甲状腺状态（正常、甲状腺功能减退）的雌性Wistar大鼠暴露于0、3或30毫克/千克体重的阻燃剂六溴环十二烷（HBCD）中7天。评估通过二维差异凝胶电泳（2D-DIGE）获得的蛋白质模式变化，并根据动物的暴露情况和甲状腺状态对不同动物组进行比较。通过质谱鉴定在这些比较中的任何一项中丰度有显著变化的蛋白质。这些数据与动物的激素数据一起在《六溴环十二烷（HBCD）诱导正常和甲状腺功能减退雌性大鼠肝脏蛋白质组的变化》（米勒等人，2016年）[1]中进行了讨论。
