KLF4 启动腺泡细胞重编程，是胰腺发生早期所必需的。
KLF4 Initiates Acinar Cell Reprogramming and Is Essential for the Early Stages of Pancreatic Carcinogenesis.
机构信息
Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-4863, USA.
Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-4863, USA.
出版信息
Cancer Cell. 2016 Mar 14;29(3):247-248. doi: 10.1016/j.ccell.2016.02.019.
Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and is minimally responsive to current chemotherapies. In this issue of Cancer Cell, Xie et al. (2016) identify the transcription factor KLF4 as essential for the early stages of pancreatic carcinogenesis, expanding the repertoire of targets for early intervention strategies.
胰腺导管腺癌（PDA）预后极差，对目前的化疗反应甚微。在本期《癌细胞》杂志上，谢等人（2016 年）发现转录因子 KLF4 对胰腺癌变的早期阶段至关重要，这扩大了早期干预策略的靶标范围。
Zotero 插件