Pavlova T V, Malyutina E S, Petrukhin V A
Belgorod State National Research University, Belgorod, Russia.
Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia.
Arkh Patol. 2015 Sep-Oct;77(5):14-17. doi: 10.17116/patol201577514-17.
to compare the clinical and morphological parallels of the mother-placenta-fetus system in diffuse toxic goiter (DTG) through current morphological examinations.
Sixty-five women whose pregnancy occurred with DTG were examined using both clinical and morphological studies (light, scanning electron, and atomic-force microscopies and macro- and microelement analysis); the placenta and uterus were investigated.
Destructive changes and microrelief impairment, resulting from circulatory disorders (ischemia) and hemic hypoxia, were observed in the presence of DTG during pregnancy. Abnormal placental immaturity developed; the number of terminal villi decreased; sclerosis occurred. The magnitude of changes showed up to a greater extent in the myometrium, umbilical cord, and placenta of women, whose pregnancy occurred with DTG, and in patients with disease recurrence. In preeclampsia, plethora, stasis, and thrombosis were added to circulatory disorders.
Not only the diagnosis itself of DTG, but also the type of its course and the pattern of obstetric disease, primarily preeclampsia, affect the state of structural components of the uteroplacental unit.
通过当前的形态学检查，比较弥漫性毒性甲状腺肿（DTG）患者母-胎-胎盘系统的临床和形态学相似性。
对65例孕期患有DTG的女性进行临床和形态学研究（光学显微镜、扫描电子显微镜、原子力显微镜检查以及常量和微量元素分析）；对胎盘和子宫进行研究。
孕期患有DTG时，观察到由循环障碍（缺血）和血液性缺氧导致的破坏性变化和微表面形态损伤。胎盘出现异常成熟障碍；终末绒毛数量减少；发生硬化。这些变化的程度在孕期患有DTG的女性的子宫肌层、脐带和胎盘中以及疾病复发患者中更为明显。在子痫前期中，循环障碍还伴有多血、淤血和血栓形成。
DTG的诊断本身、其病程类型以及产科疾病模式（主要是子痫前期）不仅会影响子宫胎盘单位结构成分的状态。
