Rodrigues Jose F, Paulovich Fernando V, de Oliveira Maria Cf, de Oliveira Osvaldo N
Institute of Mathematics & Computer Science, University of Sao Paulo (USP), 13560-970 Sao Carlos, SP, Brazil.
Sao Carlos Institute of Physics, University of Sao Paulo (USP), CP 369, 13560-970 Sao Carlos, SP, Brazil.
Nanomedicine (Lond). 2016 Apr;11(8):959-82. doi: 10.2217/nnm.16.35. Epub 2016 Mar 16.
An overview is provided of the challenges involved in building computer-aided diagnosis systems capable of precise medical diagnostics based on integration and interpretation of data from different sources and formats. The availability of massive amounts of data and computational methods associated with the Big Data paradigm has brought hope that such systems may soon be available in routine clinical practices, which is not the case today. We focus on visual and machine learning analysis of medical data acquired with varied nanotech-based techniques and on methods for Big Data infrastructure. Because diagnosis is essentially a classification task, we address the machine learning techniques with supervised and unsupervised classification, making a critical assessment of the progress already made in the medical field and the prospects for the near future. We also advocate that successful computer-aided diagnosis requires a merge of methods and concepts from nanotechnology and Big Data analysis.
本文概述了构建基于整合和解释来自不同来源和格式的数据的精确医学诊断计算机辅助诊断系统所涉及的挑战。与大数据范式相关的大量数据和计算方法的可用性带来了这样的希望,即此类系统可能很快在常规临床实践中可用,但目前情况并非如此。我们专注于对通过各种基于纳米技术的技术获取的医学数据进行视觉和机器学习分析,以及大数据基础设施的方法。由于诊断本质上是一项分类任务,我们通过监督和无监督分类来探讨机器学习技术,对医学领域已经取得的进展和近期前景进行批判性评估。我们还主张,成功的计算机辅助诊断需要融合纳米技术和大数据分析的方法和概念。