Yenigun Alper, Sezen Seda, Calim Omer Faruk, Ozturan Orhan
Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
Am J Rhinol Allergy. 2016 Mar-Apr;30(2):e21-5. doi: 10.2500/ajra.2016.30.4296.
Allergic rhinitis is a type 1 hypersensitivity reaction of the nasal mucosa, the primary mediator of which is immunoglobulin E. Allergic rhinitis occurs in children and adolescents.
This study examined the relationship between allergies and the eosinophil-to-lymphocyte ratio in children with allergic rhinitis with a positive skin-prick test.
This study was planned and performed as a case-control study.
There were 695 patients who presented to our clinic who were enrolled in the study. Only group 4 fit the criteria for allergic rhinitis. Group 1 (nonsensitized asymptomatic [control group]), group 2 (nonsensitized symptomatic), group 3 (sensitized asymptomatic), and group 4 (sensitized symptomatic). The patients' allergy symptoms and skin test results were assessed and compared. The eosinophil-to-lymphocyte ratio for each patient was calculated. The eosinophil and lymphocyte counts and the eosinophil-to-lymphocyte ratio were calculated for each group.
The eosinophil-to-lymphocyte ratio and eosinophil counts in groups 3 and 4 were significantly higher (p < 0.001 and p < 0.001, respectively) than those in groups 1 and 2. The lymphocyte counts in groups 3 and 4 were significantly lower (p = 0.046) than those of groups 1 and 2.
The eosinophil-to-lymphocyte ratio may be used in conjunction with skin-prick testing in pediatric patients with allergic rhinitis. This parameter is inexpensive to measure and easy to use and calculate.
变应性鼻炎是鼻黏膜的1型超敏反应，其主要介质是免疫球蛋白E。变应性鼻炎发生于儿童和青少年。
本研究探讨皮肤点刺试验阳性的变应性鼻炎患儿过敏与嗜酸性粒细胞与淋巴细胞比值之间的关系。
本研究作为一项病例对照研究进行规划和实施。
共有695名到我们诊所就诊的患者纳入本研究。只有第4组符合变应性鼻炎标准。第1组（未致敏无症状[对照组]）、第2组（未致敏有症状）、第3组（致敏无症状）和第4组（致敏有症状）。对患者的过敏症状和皮肤试验结果进行评估和比较。计算每名患者的嗜酸性粒细胞与淋巴细胞比值。计算每组的嗜酸性粒细胞和淋巴细胞计数以及嗜酸性粒细胞与淋巴细胞比值。
第3组和第4组的嗜酸性粒细胞与淋巴细胞比值和嗜酸性粒细胞计数显著高于第1组和第2组（分别为p<0.001和p<0.001）。第3组和第4组的淋巴细胞计数显著低于第1组和第2组（p = 0.046）。
嗜酸性粒细胞与淋巴细胞比值可与皮肤点刺试验联合用于变应性鼻炎患儿。该参数测量成本低，易于使用和计算。
