Dogru Mahmut, Evcimik Muhammed Fatih, Cirik Ahmet Adnan
Department of Pediatrics, Zeynep Kamil Woman and Children's Diseases Training and Research Hospital, Istanbul, Turkey.
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Eur Arch Otorhinolaryngol. 2016 Oct;273(10):3175-8. doi: 10.1007/s00405-015-3819-y. Epub 2015 Nov 2.
Neutrophil lymphocyte ratio (NLR) could be an important measure of systemic inflammation. There is a lack of knowledge about the neutrophil-lymphocyte ratio in rhinitis. We aimed to determine the relationship between the clinical parameters of allergic rhinitis and NLR in children. 438 children who were diagnosed with allergic rhinitis and followed up in our hospital were included in the study. The control group included 180 control children with no evidence of allergic disease. The immunoglobulin E levels, skin prick tests and complete blood count were measured. Mean NLR was 1.77 ± 1.67 in the study group and 1.70 ± 1.65 in the control group. Mean NLR was significantly higher in children with allergic rhinitis compared to controls (p < 0.05). The patients with allergic rhinitis were grouped according to the severity of AR as Group I (mild group) and Group II (moderate/severe group). No statistically significant difference was present between groups in terms of gender, age, familial atopy, exposure to smoke, the presence of asthma and/or eczema, the percentage of eosinophil, serum IgE levels, number of positive sensitivity, and sensitivity to allergens (p > 0.05). However, NLR was significantly higher in the moderate/severe AR compared to mild AR (p < 0.05). Mean NLR was statistically higher in children with allergic rhinitis compared to the control group. In addition, elevated ratio is associated with the severity of allergic rhinitis in children. Neutrophil-lymphocyte can be used as an indicator of inflammation in allergic rhinitis. But further studies are needed in this issue.
中性粒细胞与淋巴细胞比值（NLR）可能是全身炎症的一项重要指标。目前对鼻炎患者中性粒细胞与淋巴细胞比值的了解尚少。我们旨在确定儿童过敏性鼻炎临床参数与NLR之间的关系。本研究纳入了438例在我院诊断为过敏性鼻炎并接受随访的儿童。对照组包括180例无过敏性疾病证据的对照儿童。检测了免疫球蛋白E水平、皮肤点刺试验及血常规。研究组的平均NLR为1.77±1.67，对照组为1.70±1.65。过敏性鼻炎患儿的平均NLR显著高于对照组（p<0.05）。根据变应性鼻炎（AR）的严重程度，将过敏性鼻炎患者分为I组（轻度组）和II组（中度/重度组）。两组在性别、年龄、家族性特应性、接触烟雾情况、是否存在哮喘和/或湿疹、嗜酸性粒细胞百分比、血清IgE水平、阳性敏感数及对过敏原的敏感性方面，差异均无统计学意义（p>0.05）。然而，中度/重度AR患者的NLR显著高于轻度AR患者（p<0.05）。过敏性鼻炎患儿的平均NLR在统计学上高于对照组。此外，升高的比值与儿童过敏性鼻炎的严重程度相关。中性粒细胞与淋巴细胞比值可作为过敏性鼻炎炎症的一项指标。但在这个问题上还需要进一步研究。
