Posadas Inmaculada, Monteagudo Silvia, Ceña Valentín
Unidad Asociada Neurodeath, Facultad de Medicina, Universidad de Castilla-La Mancha, Albacete, Spain.
CIBERNED, Instituto de Salud Carlos III, Madrid, Spain.
Nanomedicine (Lond). 2016 Apr;11(7):833-49. doi: 10.2217/nnm.16.15. Epub 2016 Mar 16.
The poor access of therapeutic drugs and genetic material into the central nervous system due to the presence of the blood-brain barrier often limits the development of effective noninvasive treatments and diagnoses of neurological disorders. Moreover, the delivery of genetic material into neuronal cells remains a challenge because of the intrinsic difficulty in transfecting this cell type. Nanotechnology has arisen as a promising tool to provide solutions for this problem. This review will cover the different approaches that have been developed to deliver drugs and genetic material efficiently to the central nervous system as well as the main nanomaterials used to image the central nervous system and diagnose its disorders.
由于血脑屏障的存在，治疗药物和遗传物质难以进入中枢神经系统，这常常限制了有效无创治疗和神经系统疾病诊断方法的发展。此外，由于转染神经元细胞存在内在困难，将遗传物质递送至神经元细胞仍然是一项挑战。纳米技术已成为解决这一问题的一种有前景的工具。本综述将涵盖为有效向中枢神经系统递送药物和遗传物质而开发的不同方法，以及用于中枢神经系统成像和诊断其疾病的主要纳米材料。
