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头颈部梭形细胞变异型鳞状细胞癌中的肿瘤生物标志物

Tumor Biomarkers in Spindle Cell Variant Squamous Cell Carcinoma of the Head and Neck.

作者信息

Rosko Andrew J, Birkeland Andrew C, Wilson Kevin F, Muenz Daniel G, Bellile Emily, Bradford Carol R, McHugh Jonathan B, Spector Matthew E

机构信息

Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.

Department of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.

出版信息

Otolaryngol Head Neck Surg. 2016 Jul;155(1):106-12. doi: 10.1177/0194599816636612. Epub 2016 Mar 15.

DOI:10.1177/0194599816636612
PMID:26980915
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4930715/
Abstract

OBJECTIVE

To determine biomarkers of recurrence and survival in patients with spindle cell variant squamous cell carcinoma (SpSCC) of the head and neck.

STUDY DESIGN

Retrospective case control study.

SETTING

Tertiary academic center.

SUBJECTS AND METHODS

Thirty-two SpSCC patients (mean age, 68.8) between 1987 and 2009 were identified and reviewed. A tissue microarray (TMA) was constructed from tumor specimens. Tumor biomarkers under study included p16, epidermal growth factor receptor (EGFR), p53, EZH2, cyclin D1, CD104, HGFa, p21, and cMET. An additional TMA was constructed from patients with non-SpSCC oral cavity squamous cell carcinoma for comparative purposes. The main outcomes were overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS).

RESULTS

In the SpSCC cohort, tumors positive for cMet had worse OS (P < .001). Patients positive for cMet (P = .007), cyclin D1 (P = .019), and p16 (P = .004) had worse DSS. Recurrence-free survival was also worse in patients with tumors positive for cMet (P = .037), cyclin D1 (P = .012), and p16 (P < .001). Compared with the oral cavity cohort, there was a significantly larger proportion of patients in the SpSCC group with tumors staining positive for cMet and a lower proportion of tumors positive for cyclin D1.

CONCLUSION

cMet, cyclin D1, and p16 are predictive tumor biomarkers for risk of recurrence and worse DSS in patients with SpSCC.

摘要

目的

确定头颈部梭形细胞变异型鳞状细胞癌（SpSCC）患者复发和生存的生物标志物。

研究设计

回顾性病例对照研究。

研究地点

三级学术中心。

研究对象与方法

确定并回顾了1987年至2009年间的32例SpSCC患者（平均年龄68.8岁）。从肿瘤标本构建组织微阵列（TMA）。所研究的肿瘤生物标志物包括p16、表皮生长因子受体（EGFR）、p53、EZH2、细胞周期蛋白D1、CD104、HGFa、p21和cMET。为作比较，从非SpSCC口腔鳞状细胞癌患者中构建了另一TMA。主要结局为总生存期（OS）、疾病特异性生存期（DSS）和无复发生存期（RFS）。

结果

在SpSCC队列中，cMet阳性的肿瘤患者OS较差（P <.001）。cMet阳性（P =.007）、细胞周期蛋白D1阳性（P =.019）和p16阳性（P =.004）的患者DSS较差。cMet阳性（P =.037）、细胞周期蛋白D1阳性（P =.012）和p16阳性（P <.001）的患者无复发生存期也较差。与口腔队列相比，SpSCC组中cMet染色阳性的肿瘤患者比例显著更高，而细胞周期蛋白D1阳性的肿瘤比例更低。

结论

cMet、细胞周期蛋白D1和p16是SpSCC患者复发风险和较差DSS的预测性肿瘤生物标志物。

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